Associate Director/Sr. Manager, Health Economics & Outcomes Research-Oncology

Position Summary

• We are seeking a strategic, analytical, and highly collaborative leader to serve as our
• Associate Director/Senior Manager of Health Economics & Outcomes Research
• (HEOR) Oncology. In this high-impact role, you will lead the development and execution
• of health economic and outcomes evidence demonstrating the clinical and economic
• value of Natera’s precision molecular diagnostic technologies across oncology and
• emerging indications.

• You will develop health economic models, generate real-world and clinical-trial
• evidence, lead HEOR publication initiatives, and translate complex clinical and
• economic data into compelling evidence supporting market access, reimbursement,
• payer adoption, clinical adoption, and commercialization. Working across Medical
• Affairs, Clinical Development, Biostatistics, Market Access, Commercial, Marketing,
• Regulatory, and Business Development, you will help integrate HEOR evidence
• throughout the product lifecycle—from clinical development and evidence generation
• through publication, reimbursement, and payer adoption.

• This is a strategic role for an experienced HEOR professional who combines strong
• technical capabilities with scientific communication, business acumen, and the ability to
• influence cross-functional evidence strategy.

Why Join Us

• At Natera, you will have the opportunity to shape the economic evidence strategy
• supporting innovative precision diagnostics and biomarker-guided approaches to patient
• care. You will work at the intersection of clinical evidence, health economics, market
• access, and commercialization, translating clinical innovation into measurable value for
• patients, providers, health systems, and payers.

• You will collaborate with internal leaders, investigators, key opinion leaders, and
• external research partners to generate evidence capable of influencing reimbursement
• decisions, clinical adoption, health technology assessments, and healthcare policy
• across U.S. and global markets.

Key Responsibilities

•  Health Economic Modeling & Value Demonstration: Lead the development,
• validation, and application of health economic models, including budget impact,
• cost-effectiveness, cost-utility, cost-consequence, ROI, decision-tree,
• Markov/state-transition, partitioned-survival, and other economic models.
• Develop scenario and sensitivity analyses that quantify the clinical and economic
• value of precision diagnostics across different payer and healthcare-system
• perspectives.

•  Clinical Development & HEOR Evidence Strategy: Partner with Clinical
• Development, Medical Affairs, Biostatistics, and other cross-functional teams to
• integrate HEOR objectives into prospective clinical studies, including healthcare
• resource utilization, economic endpoints, patient-reported outcomes, quality-of-
• life measures, cost-data collection, and real-world evidence strategies. Ensure
• evidence-generation plans anticipate future payer, reimbursement, and HTA
• requirements.

•  Real-World Evidence & Outcomes Research: Analyze clinical-trial,
• observational, and real-world datasets to evaluate healthcare resource utilization,
• cost of care, treatment pathways, diagnostic utilization, clinical utility, comparative
• effectiveness, patient outcomes, survival, budget impact, and quality-adjusted life
• years. Translate findings into actionable evidence supporting clinical, payer, and
• business decisions.

•  Publication & Scientific Evidence Leadership: Lead HEOR publication
• strategy and development of peer-reviewed manuscripts, scientific abstracts,
• conference posters, oral presentations, white papers, and technical reports.
• Coordinate publication plans and timelines with investigators, key opinion
• leaders, academic collaborators, and external research partners to ensure
• evidence generation is aligned with strategic business priorities.

•  Market Access & Payer Evidence: Partner with Market Access, Medical Affairs,
• Marketing, and Commercial teams to translate HEOR evidence into payer value
• propositions, budget impact summaries, value dossiers, reimbursement
• materials, health economic briefs, health-system value calculators, account-
• specific economic tools, and other evidence-based value communications.

•  Global HEOR Strategy: Develop and adapt health economic evidence and
• payer models for the U.S. and international markets, including Europe, Japan,
• Canada, Australia, and other priority geographies. Support reimbursement
• submissions and evidence strategies aligned with HTA and payer requirements
• across healthcare systems.

•  Cross-Functional & External Collaboration: Serve as a strategic HEOR
• partner across Medical Affairs, Clinical Development, Biostatistics, Market
• Access, Commercial, Marketing, Regulatory, and Business Development.
• Collaborate with external consultants, academic investigators, KOLs, and
• research partners to execute high-quality evidence-generation initiatives.

Core Skills & Competencies

•  Health Economics & Outcomes Research: Deep understanding of health
• economic modeling, outcomes research, healthcare resource utilization, real-
• world evidence, cost-of-care analysis, comparative effectiveness, and value
• assessment methodologies.

•  Economic Modeling: Demonstrated ability to develop and critically evaluate
• budget impact, cost-effectiveness, cost-utility, ROI, decision-tree, Markov/state-
• transition, and related economic models.

•  Payer & Market Access Strategy: Strong understanding of payer evidence
• requirements and the ability to translate clinical and economic evidence into
• compelling value propositions supporting reimbursement, coverage, and
• adoption.

•  Evidence Generation & Clinical Strategy: Ability to integrate HEOR endpoints
• and evidence requirements into clinical development and real-world research
• programs, anticipating future reimbursement and HTA needs.

•  Scientific Communication & Publication: Strong scientific writing and
• communication skills with experience translating complex analyses into
• manuscripts, abstracts, presentations, value dossiers, payer materials, and
• executive-level communications.

•  Cross-Functional Leadership: Proven ability to work across clinical, medical,
• statistical, market access, commercial, and business functions and to influence
• evidence strategy in a matrixed organization.

•  Global Perspective: Understanding of U.S. and international reimbursement
• environments and major HTA frameworks, including ICER, NICE, CADTH,
• PBAC, IQWiG, and Japanese reimbursement processes.

Qualifications

•  Advanced degree (PhD, PharmD, MD, DrPH, or Master's degree) in Health
• Economics, Outcomes Research, Epidemiology, Public Health, Biostatistics,
• Pharmacy, Health Services Research, or a related discipline.

•  5–10+ years of HEOR experience within biotechnology, pharmaceuticals,
• diagnostics, medical devices, consulting, academia, or a related healthcare
• environment.

•  Demonstrated experience developing and applying health economic models and
• conducting outcomes research using clinical-trial and/or real-world datasets.

•  Experience supporting payer evidence generation, reimbursement strategy, value
• dossiers, market access initiatives, and scientific publications.

•  Experience with precision medicine, molecular diagnostics, companion
• diagnostics, ctDNA, molecular residual disease (MRD), donor-derived cell-free
• DNA (dd-cfDNA), next-generation sequencing, biomarker-guided treatment
• strategies, or oncology diagnostics is highly desirable.

•  Familiarity with advanced economic and analytical tools such as Microsoft Excel,
• TreeAge Pro, R, SAS, STATA, Python, SQL, Tableau/Power BI, and statistical
• analysis software is preferred.

The pay range is listed and actual compensation packages are based on a wide array of factors unique to each candidate, including but not limited to skill set, years & depth of experience, certifications and specific office location. This may differ in other locations due to cost of labor considerations.