Director, Compensation

Olema Oncology is a clinical-stage biopharmaceutical company committed to transforming the standard of care and improving outcomes for patients living with breast cancer and beyond. It’s an exciting time to be part of Team Olema , with our transfor mation into a fully integrated oncology company well underway , t op-line data from our lead program expected later this year , and our first potential commercial launch on the horizon.

Our lead product candidate, palazestrant, is a novel, orally available complete estrogen receptor antagonist (CERAN) and selective estrogen receptor degrader (SERD) currently in two pivotal Phase 3 clinical trials. We expect top-line data from OPERA-01, our ongoing Phase 3 trial of palazestrant as a monotherapy in patients with second- or third-line ER+/HER2- metastatic breast cancer (MBC), in the fall which, if successful, could lead to our first potential approval and commercial launch in 2027. OPERA-02, our Phase 3 trial of palazestrant in combination with ribociblib in patients with frontline ER+/HER2- MBC, is enrolling patients. Together with its mechanism of action, pharmacokinetic properties, and the potential to demonstrate activity in both ESR1 wild-type and mutant tumors, palazestrant has the potential to transform the metastatic breast cancer treatment paradigm and access a $15 billion global market opportunity.

Our follow-on product candidate, OP-3136, is a potent KAT6 inhibitor with the potential to generate further value and meaningfully impact the metastatic breast cancer treatment landscape – particularly in combination with palazestrant. We recently reported encouraging Phase 1 monotherapy data from this program across multiple solid tumor types and are advancing patient enrollment in the ongoing combination arms in MBC.

Aspiring to transform the metastatic treatment paradigm is an ambitious endeavor that requires a resolute approach to developing better therapies and a passionate team dedicated to helping the patients we serve feel better, longer. We possess a deep commitment to our shared purpose, the sustained pursuit of excellence, cultivating the courage required to advance our programs, drive to succeed, and a collective capacity for adaptability through learning, growth, and evolution. Team Olema is made up of nimble self-starters who bring consistency in their quest for the extraordinary every single day.

If you’re ready to be part of a tenacious, courageous, agile, and growing team, join us in making a profound impact, together – for our patients, for your career, and for what’s beyond .

At Olema, our shared purpose - developing better medicines for people living with cancer - depends on attracting, rewarding, and retaining exceptional people. As the company grows and prepares for commercialization, we are seeking our first dedicated compensation expert as the Director, Compensation to establish this capability with the rigor, thoughtfulness, and adaptability our next stage requires.

Reporting to the SVP, People & Culture, this highly influential position will serve on the People & Culture Leadership Team and partner closely with HR Business Partners, senior leaders, and the Executive Team. This person will create the frameworks, processes, and trusted expertise needed to support consistent, competitive, and well-informed compensation decisions for employees at the Vice President level and below.

This individual will own the design, implementation, administration, communication, and governance of all non-executive compensation programs across the organization, including broad-based compensation, equity programs, and future commercial and sales compensation structures. The role will also partner closely with the SVP, People & Culture in supporting executive compensation and Compensation Committee activities through market analyses, data insights, modeling, and strategic recommendations.

The ideal candidate brings deep biotech and/or pharmaceutical industry expertise, experience supporting organizations through both clinical and commercial growth stages, and a demonstrated ability to operate strategically while remaining hands-on in a lean, high-growth environment.

The right candidate will bring technical excellence across compensation budgeting, focal cycles, market benchmarking, job architecture, leveling, salary structures, equity, and data integrity. Just as important, they will be curious, pragmatic, and collaborative- —someone who asks thoughtful questions, applies sound business judgment, and develops solutions that reflect Olema’s business priorities, culture, and commitment to its people.

This is a hybrid position based out of our San Francisco or Boston office.

Key Responsibilities

Experience supporting an organization as it progresses from clinical development toward commercialization.

Experience preparing executive compensation benchmarking, analyses, background information, and documentation for inclusion in Compensation Committee materials.

Experience operating as a senior individual contributor in a lean, high-growth environment, with the ability to establish compensation expertise without creating unnecessary complexity.

Compensation Strategy & Leadership

Contribute to and evolve Olema’s compensation philosophy, strategy, and frameworks to support business objectives, organizational growth, talent attraction, retention, and performance.

Serve as the company-wide subject matter expert on non-executive compensation matters.

Build scalable compensation infrastructure, processes, governance, and policies appropriate for a growing biotech organization transitioning toward commercialization.

Partner closely with the SVP, People & Culture and business leaders on compensation strategy, workforce planning, and organizational design considerations.

Broad-Based Compensation

Own and administer broad-based compensation programs across all non-executive levels and functions.

Lead market benchmarking, job architecture, leveling, salary structures, and compensation planning processes.

Drive annual compensation focal review processes including merit, bonus, and equity planning cycles.

Provide strategic compensation guidance to business leaders and People Business Partners on hiring, promotions, internal equity, retention, and organizational changes.

Develop scalable cash compensation frameworks that support organizational growth, high volume recruitment, while maintaining consistency and internal equity.

Commercial & Sales Compensation

Partner with Commercial leadership to develop incentive compensation structures aligned with business strategy, market dynamics, performance objectives, and evolving commercial capabilities.

Establish sales compensation governance, metrics, administration processes, modeling, and effectiveness analyses.

Develop compensation approaches that support the successful build-out and growth of a high-performing commercial organization.

Equity Compensation

Partner cross-functionally with Legal, Finance, Payroll, and external vendors to support equity compensation administration and governance.

Support equity strategy and recommendations aligned with talent and business objectives.

Ensure appropriate controls, compliance, and reporting related to equity programs.

Executive Compensation Support

Partner closely with the SVP, People & Culture in supporting executive compensation programs and Compensation Committee activities.

Provide market benchmarking, analyses, modeling, and materials to support executive compensation decision-making and Board discussions.

Collaborate with external compensation consultants and internal stakeholders on executive compensation-related initiatives as needed.

Compliance, Governance & Analytics

Ensure compliance with all applicable federal, state, and international compensation-related laws and regulations.

Maintain strong compensatio