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hirly last saw it live on 1 September 2026. Similar roles are on the live board.

Prolaio

Principal Product Designer

Chicago, IL

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Role family
Design
Seniority
Lead / management
Stated salary
$154,000 per year
Country
US
Work mode
On-site / unstated
First seen by hirly
1 Sept 2026

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the posting

Who Are We?

Prolaio believes that continuous learning and collaboration can make a significant difference in how heart care is administered. We are creating smarter ways to address heart disease and heart risks by uniting patients, care teams, and researchers on a secure, technology-enabled platform that drives clinical innovation and offers a path towards better patient outcomes.

This is precision cardiology, and we know it’s within reach.

What Will You Do?

The Overview

The Principal Product Designer to own the end-to-end design of our products — from early-stage discovery through polished, production-ready interfaces. This is a foundational hire at a critical stage of growth. You will be the design voice in the room: following standards, collaborating with Product & Engineering, and delivering work that meets both the needs of clinicians and patients.

This individual contributor role is ideal for a seasoned generalist who is comfortable with ambiguity and confident in using their craft to create clarity. A strong candidate will be equally skilled in gathering requirements, building information architecture, and crafting high-fidelity UI.

The Specifics

Define and drive long-term product vision and design strategy for multiple products. Lead complex, ambiguous design problems from conceptual exploration through detailed execution.

Partner with Product Manager and Engineering teams to conduct workshops, feature definition, and stakeholder management

Collaborate with clinical, regulatory, and legal teams to translate user needs into design artifacts and specifications

Design high-fidelity mockups and interactive prototypes for user research and development handoff

Update organization regularly on product design progress.

Represent the design perspective for broad, non-technical audience

Why Prolaio?

Impactful Work: You will join in the fight against heart failure (HF) and hypertrophic cardiomyopathy (HCM) with the goal of extending and saving the lives of our patients while also being at the forefront of changing the healthcare industry through technology.

Innovative Environment : You will be part of an organization doing something that’s never been done before.

Professional Growth : You will join a growing team and have a substantial impact on our daily and future operations with the opportunity to continuously learn and grow.

Collaborative Team : You will be part of a team of collaborative, curious, and committed individuals focused on the collective good, inclusiveness, scientific excellence, and advancing digital health for cardiology.

Who You Are?

7+ years of product or UX/UI design experience, including 3 years in a senior or principal-level role

Portfolio demonstrating end-to-end of complex product design, ranging from long term product vision, to detailed execution

Hands-on experience designing for regulated industries, preferably medical devices, health IT, or clinical software

Strong organization, written, and verbal communication skills, including ability to document design rationale and detailed specifications.

Working understanding of product management and development processes, with demonstrated experience collaborating with those disciplines

Why You’ll Love Working Here

Meaningful Compensation : Competitive salary, performance bonus, and equity so you can share in what we build.

Great Health Coverage: Medical, dental, and vision plans with multiple options and strong company contributions.

Flexible Spending Perks: HSA, FSA, commuter benefits, and a $1,200 annual Lifestyle Spending Account to support wellness, commuting, family needs, and more.

Time to Recharge: Generous paid time off, sick leave, and company holidays.

Family-First Benefits : Paid parental leave, caregiver leave, and support for growing families.

Security & Peace of Mind : Company-paid life insurance and short- and long-term disability coverage.

Plan for the Future : 401(k) plan to help you build long-term financial security.

Care When You Need It: Easy access to telehealth and optional supplemental coverage for life’s unexpected moments.

Starting Salary is at $154,000.00 (Exact Compensation may vary based on skills, experience, and location)

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Principal Product Designer at Prolaio — hirly