Raven StealthCo - Principal Scientist, In Vivo Pharmacology

• About Raven:
• We are Raven, RA Capital’s healthcare incubator. From discovery to delivery, whether we incubate, accelerate or rejuvenate, Raven’s goal is to turn scientific breakthroughs into transformative therapies and get them quickly, safely and efficiently to the patients that need them most. Raven’s experienced scientists, operators, and healthcare innovators have deep sector expertise across therapeutics, diagnostics, devices and services. They have brought hundreds of therapeutics into development, managed hospital systems, optimized clinical trials and navigated payor and regulatory systems to deliver patient impact - and they are ready to work with you.

• About RA Capital:
• Founded in 2004, RA Capital Management is a multi-stage investment manager dedicated to evidence-based investing in public and private healthcare, life sciences, and planetary health companies. RA Capital creates and funds innovative companies, from private seed rounds to public follow-on financings, allowing management teams to drive value creation from inception through commercialization and beyond. RA Capital's knowledge engine is guided by our TechAtlas internal research division, and Raven, RA Capital’s company building team, offers entrepreneurs and innovators a collaborative and comprehensive platform to explore the novel and the re-imagined. RA Capital has more than 150 employees and over $10 billion in assets under management.

Company Background

We are a well-funded, stealth-mode biotechnology focused on next generation oligo-based modalities targeting tissues beyond the liver, muscle, and kidney. We are building a platform to deliver oligos with high precision to previously untargeted cells, while focused on “undruggable” genes, alone or in combination with previously validated targets. Many of our targets carry "pipeline-in-a-drug" potential: a single gene or protein with meaningful biological effects across multiple disease areas. Headquartered in Cambridge, Massachusetts, the company was incubated in RA Capital’s venture group (Raven) and is led by an experienced CEO. After a robust incubation and vetting process, Raven StealthCo was launched and funded by RA Capital. The company’s therapeutic areas of interest lie outside commonly targeted cells and tissues, and represent multi-billion-dollar markets that are continuing to grow as the population ages. Our initial focus is creating transformational therapies to treat diseases, but given the platform potential, we have longer-term ambitions to address healthy aging. These targets are backed by strong biological and genetic evidence but have historically resisted small molecule and biologic approaches. Raven StealthCo is moving quickly to address multiple disease indications at scale and with significant market potential.

Opportunity

We are in the discovery stage and will invest heavily in our emerging platform for oligonucleotide delivery. Our disease focus is supported by highly predictive animal models with strong translatability to humans, offering a potentially rapid and efficient path to the clinic. Given our recent funding and commitment to building a first-in-class platform, we are recruiting a Principal Scientist / Associate Director, In Vivo Pharmacology to design, manage, and interpret the externally executed studies that establish pharmacokinetics, target engagement, pharmacodynamics, and efficacy for our programs.

The Position

The Principal Scientist reports to the Director of Biology and Pharmacology and leads the company’s in vivo pharmacology efforts, owning how studies are designed, run, and analyzed. Working in close partnership with the Director, who sets the overall biology and pharmacology strategy in accordance with the company goals and broad scientific strategy, this person translates that strategy into a rigorous in vivo program and drives it end to end.

In vivo studies will be run externally at contract research organizations while the ex vivo analyses will be executed both internally and externally. The Principal Scientist’s focus will be the design, direction, and interpretation of that work rather than its hands-on execution. The successful candidate will be point of contact for day to day management including study design, CRO scoping and oversight, sample logistics, tissue-processing support, and data interpretation. This will be an individual contributor role at hire, with clear room to expand in scope and influence as the portfolio and team grow.

Specific responsibilities include:

Partner with the Director to set the staged in vivo pharmacology plan (target validation and proof-of-concept through dose-response, duration of effect, and candidate selection and development), and own its execution

Design the CRO-executed rodent and non-human-primate studies (controls, power, pre-specified endpoints) and author the protocols and analysis plans

Qualify and manage CRO partners for in vivo studies and outsourced analytics (scope, budget, timeline, quality), serving as day-to-day scientific contact from pre-study alignment through in-life monitoring and troubleshooting

Select, qualify, and de-risk the in vivo models, setting performance, variability, and effect-size expectations before pivotal studies

Own the in vivo endpoint suite: quantitative histology and morphometry, tissue-based PD readouts, circulating and tissue biomarkers, and -omics readouts as needed

With the delivery and analytical chemistry groups, connect biodistribution and tissue exposure to pharmacodynamics and phenotype, and design and interpret the PK/PD studies that set exposure–activity–efficacy relationships for dose, schedule, and duration

Define the in vivo and translational biomarker plan carrying programs from research into development, aligned with overall program strategy

Own sample logistics for in vivo studies (receipt, cataloging, storage, chain of custody, and shipment to and from CRO and analytical partners), specifying per study which tissues and readouts are needed and handing samples to the in vitro scientist for execution

Provide hands-on support for tissue processing so samples reach downstream analysis fit for purpose

Benchmark candidates against standard-of-care and mechanistic comparators, and contribute to IND-enabling and larger-species study design and the nonclinical narrative as programs mature

Provide sponsor-side data integrity, documentation, and animal-welfare oversight of external studies (CRO and IACUC review, chain of custody, reproducibility) for an eventual regulatory package, and build the in vivo record-keeping, data, and protocol templates the group runs on

Mentor junior team members and help grow the team as remits expand

Bring in vivo results, their program implications, and competitive-landscape intelligence into cross-functional and leadership discussion, help shape how in vivo findings reach the Board, investors, and partners, and contribute to publications, patents, and presentations

The Individual

The Principal Scientist can design a study, direct its execution through a third party, and defend its interpretation. Because our in vivo work is externalized, they must anticipate where a model will fail, recognize when data quality has drifted, and know which questions to ask before a study, not after, with the judgment to separate a real pharmacologic effect from an artifact of model, timing, or analysis.

Equally important is ownership: someone who treats the in vivo package as theirs to deliver, anticipating needs, raising concerns early, and following issues to resolution unprompted. They bring independent, well-reasoned thinking to the in vivo strategy and partner closely with the Director to shape it, going deep as the in vivo pharmacology expert the rest of the team relies on. Experience mentoring juniors is welcome; the appetite to build rigorous in vivo practice from the ground up matters more than a long management reco