Senior Manager, Global Value and Access

Company Overview

Immunome is a clinical-stage targeted oncology company committed to developing first-in-class and best-in-class targeted cancer therapies. We are advancing an innovative portfolio of therapeutics, supported by a leadership team with deep experience in the design, development, and commercialization of cutting-edge therapies, including antibody-drug conjugates. Our pipeline includes varegacestat, an investigational gamma secretase inhibitor for which an NDA has been accepted by the U.S. FDA; IM-1021, a clinical-stage ROR1 ADC; IM-1617, a clinical-stage solid tumor ADC; and IM-3050, a clinical-stage FAP-targeted radioligand therapy. We are also advancing a broad portfolio of early-stage ADCs pursuing undisclosed solid tumor targets.

Position Overview

Immunome is seeking a Senior Manager, Global Value and Access to support global health economics and outcomes research (HEOR) and market access activities in the US and ex-US for our oncology portfolio. This role will primarily lead the execution of HEOR studies and evidence-generation deliverables, while flexing into broader market access priorities as Immunome prepares for a potential launch of its lead asset, varegacestat.

The successful candidate will combine strong HEOR technical and project management capabilities with a practical understanding of US and ex-US payer evidence needs, value communication including field tools, and new drug launch. This is a highly visible opportunity for an individual who thrives in a fast-paced environment, learns quickly, and is eager to take on new responsibilities. The level will be commensurate with experience; the ideal candidate will bring enough launch exposure to add value immediately while continuing to grow across Global Value and Access.

Responsibilities

HEOR Strategy and Evidence Planning

Support integrated HEOR and real-world evidence strategies aligned with clinical development, medical, regulatory, and market access priorities.

Identify evidence gaps and translate payer, health technology assessment (HTA), and business questions into fit-for-purpose research plans and analyses.

Provide HEOR input to evidence-generation plans, value propositions, and launch- deliverables for the lead asset and broader portfolio.

HEOR Study Execution

Lead real-world evidence studies, including burden of illness, treatment patterns, healthcare resource use, real-world comparative effectiveness, and epidemiology studies using claims, electronic health records, and other secondary data sources.

Develop cost-effectiveness and budget-impact models, from early economic models that inform development and pricing strategy to submission-ready models adapted for HTA bodies ex-US.

Conduct systematic literature reviews, indirect treatment comparisons and network meta-analyses.

Develop and review study protocols, analysis plans, reports, abstracts, posters, and manuscripts; ensure scientific rigor, timely delivery, and clear communication of decision-relevant findings.

Launch Readiness and Market Access Support

Own the launch deliverables including AMCP dossier, global value dossier, budget-impact model, and cost-effectiveness models.

Flex into launch market access workstreams, contributing to payer value propositions , payer research, objection handling, and access field tools.

Translate clinical and economic evidence into clear payer narratives and materials that support reimbursement and patient access.

Monitor payer, HTA, reimbursement, policy, and competitive trends and assess implications for evidence strategy and launch execution.

Vendor and Project Management

Manage HEOR consultants, data partners, and agencies, including scope, deliverables, timelines, budgets, and quality.

Own multiple concurrent projects, proactively resolving risks and adapting priorities in a rapidly changing environment.

Ensure work meets internal standards and applicable scientific, legal, regulatory, and publication requirements.

Cross-Functional Collaboration and Communication

Serve as a Global Value and Access partner on asset and launch teams, collaborating with Clinical Development, Medical Affairs, Regulatory, Commercial, Finance, and other functions.

Influence without direct authority, communicate complex concepts clearly, and flex beyond core responsibilities with curiosity, urgency, sound judgment, and a team-first mindset.

Qualifications

Advanced degree (Ph.D., Pharm.D., M.S., M.P.H., or equivalent) in health economics, outcomes research, epidemiology, public health, pharmacy, health services research, or a related discipline preferred; a bachelor's degree with directly relevant experience will be considered.

Minimum of 3 years of work experience in HEOR, real-world evidence, market access, or a related function within biotechnology, pharmaceuticals, managed care, or consulting.

Demonstrated experience executing HEOR or real-world evidence studies from concept through final deliverable.

Track record of peer-reviewed publications and scientific presentations at HEOR or clinical congresses.

Experience translating clinical, economic, and outcomes evidence into payer value messages or market access deliverables.

Launch experience preferred but not required .

Oncology, rare disease, or specialty product experience preferred.

Experience managing external research partners, consultants, data vendors, or agencies.

Knowledge and Skills

Strong project management skills and ability to independently drive multiple high-priority workstreams against tight timelines.

Ability to critically evaluate study designs and analyses and communicate actionable conclusions.

Sound understanding of U.S. and global payer, reimbursement, HTA, and evidence requirements.

Excellent written and verbal communication skills, including scientific writing and presentation capabilities.

High learning agility, intellectual curiosity, passion, and drive to take on new challenges and grow quickly.

Hands-on, resourceful, and comfortable operating with ambiguity in a fast-paced, dynamic biotechnology environment.

Collaborative working style with a willingness to flex across HEOR and market access priorities.

Exceptional organizational, analytical, problem-solving, and judgment skills, with close attention to detail.

Washington State Pay Range

$179,611 — $211,641 USD

E/E/O

Immunome, Inc. is an equal opportunity employer. We celebrate diversity and are committed to creating an inclusive environment for all employees.

E-Verify

Immunome, Inc. is a participant in E-Verify. Please review the following notices: E-Verify Participation Poster | Right to Work Poster (English) | Right to Work Poster (Spanish) .