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Disc Medicine

Senior Manager, Payroll and Equity

Massachusetts - Hybrid

hirly's read of this role

Seniority
Lead / management
Work mode
Remote-friendly
First seen by hirly
14 Sept 2026

Derived automatically from the posting.

the posting

Join our team in a dynamic hybrid role, offering flexibility to work remotely or from our headquarters in Watertown, MA.

COMPANY OVERVIEW:

Disc Medicine is a clinical-stage biopharmaceutical company committed to discovering, developing, and commercializing novel treatments for patients who suffer from serious hematologic diseases. We are building a portfolio of innovative, first-in-class therapeutic candidates that aim to address a wide spectrum of hematologic diseases by targeting fundamental biological pathways of red blood cell biology, specifically heme biosynthesis and iron homeostasis. Disc Medicine values collaboration, professional development, and scientific integrity and promotes an inclusive company culture that empowers and inspires.

POSITION OVERVIEW :

Reporting to the Director, Finance Operations, the Senior Manager, Payroll and Equity will be responsible for the accurate, timely and compliant processing for all payroll and equity cycles, including semi-monthly payrolls, special/off-cycle payrolls, equity grants, RSU vesting, ESPP purchases and stock option exercises, as well as annual processes such as bonus payments and year-end reporting. This role requires excellence in operational execution and strong communication skills. The successful candidate has strong analytical and problem-solving skills, strong attention to detail, and is able to manage multiple workflows, partnering closely with HR, Finance, Legal, and external auditors and consultants.

RESPONSIBILITIES:

Principal Payroll Responsibilities :

Process and validate semi-monthly payrolls in ADP Workforce Now, ensuring accuracy, timeliness and SOX-compliant documentation

Support payroll processing related to equity compensation including RSU vesting, option exercises, and employee stock purchase plan (ESPP) transactions

Collaborate with HR to ensure the smooth execution of onboarding, offboarding and overall maintenance of employee compensation

Maintain payroll system accuracy, including earnings codes, deductions, tax configurations, and pay rules

Partner with ADP and other service providers to ensure accurate year-end processing and W-2 reporting; 401(k), payroll tax, and other payroll-related audits and compliance activities

Manage 401k uploads

Ensure compliance with federal, state and local laws and regulations as well as company policies and procedures. Review payroll and tax changes and provide recommendations to management to ensure company compliance

Manage multi-state processing and reporting, including state tax registrations, withholding accounts, and unemployment accounts

Perform monthly payroll reconciliations, payroll journal entries, bonus accruals and resolve any payroll discrepancies in a timely manner

Generate and analyze payroll reports using ADP Workforce Now to support Finance, HR, and audit requirements

Process Concur expense report

Provide clear, prompt, professional and accurate communication to employees regarding payroll and equity questions

Principal Equity Responsibilities :

Manage day-to-day responsibilities in the Shareworks equity system

Manage and review automatic feeds from ADP to Shareworks for demographic and tax information updates

Oversee and process quarterly RSU vesting

Monitor for employee elected changes to ESPP program to be recorded in payroll

Upload new stock grants on a monthly basis

Oversee semi-annual ESPP open enrollment window as well as ESPP purchases

Prepare annual Form 3921/3922 submissions

Support accounting with various reporting needs as required

Prepare documentation in accordance with Company’s internal SOX controls as well as support requests related to both internal and external audit testing around stock compensation activity

REQUIREMENTS:

Bachelor’s degree in Accounting, Finance, Human Resources, Business Administration, or related field

7-10+ years of hands-on multi-state payroll processing experience, ideally in high-growth environments

Experience processing payroll within ADP Workforce Now

2+ years of equity administration experience supporting stock option and RSU programs

Proficiency in Microsoft Excel, including Pivot Tables, XLOOKUP/VLOOKUP, data analysis, reconciliations, and reporting; strong working knowledge of Microsoft Office applications, including Word, PowerPoint, and Outlook

Excellent analytical, organizational, communication, and problem-solving skills, with strong attention to detail

Demonstrated ability to manage multiple concurrent deadlines with accuracy; strong sense of ownership, accountability and follow through

Demonstrated ability to handle highly confidential information with discretion and maintain the highest professional and ethical standards in a fast-paced, cross-functional environment.

Ability to work both independently and collaboratively in a high-growth, fast-paced environment

Experience managing complex tax scenarios

Experience supporting SOX, financial and compliance audits, and 401(k) plans

Preferred Requirements

Experience with Shareworks and NetSuite.

Experience in the biotechnology, pharmaceutical, or life sciences industry.

Certified Payroll Professional (CPP) and/or Certified Equity Professional (CEP) designation.

The annual base salary range for this position is listed below. Actual pay rates are determined by considering multiple factors including qualifications, relevance of experience, education & credentials, subject matter expertise, and internal parity.

Salary Range

$151,000 — $185,000 USD

Disc Medicine is an equal-opportunity employer committed to providing all qualified candidates and employees equal opportunities. We offer comprehensive benefits and competitive compensation packages. The Company headquarters are in Watertown, MA, and we provide a flexible work environment.

Disc Medicine actively recruits individuals with an entrepreneurial spirit and a drive for excellence. Interested candidates should submit their resume to be considered for current and future opportunities.

Disc Medicine respects your privacy. For information about how Disc processes your personal data in the context of your candidacy, please see our Privacy Notice .

Original posting on Disc Medicine's site ↗