Senior Scientist I Analytical Development

Alumis Inc. is a precision medicines company with the mission to transform the lives of patients with autoimmune diseases. Even with treatment innovations of the last two decades, many patients with immunologic conditions continue to suffer - our goal is to fundamentally change the outcomes for these patients.

The small molecule CMC team is seeking highly motivated Sr. Scientist I of Analytical Dev e lopment to help build our dynamic small molecule CMC group at Alumis . The successful candidate will help to support the analytical development and quality control activities from the preclinical phase through late-stage clinical development. Having analytical development expertise and experience in working with CMOs/CTLs, coupled with thorough understanding of the associated quality and regulatory awareness are key assets.

RESPONSIBILITIES

Support development, validation , and transfer of analytical methods to support starting material, intermediate, drug substance and drug product testing at CMOs/CTLs

Execute and/or support the in-house method development activities using UPLC/HPLC, LC-MS, KF, and dissolution instrumentation and technique s for Phase 1 to late-stage drug development

Review CMO/CTL analytical data (in-process, release, and stability data), protocols and reports

Trend stability and release data using statistical methods

Assist in investigation for various non-conformance events at CMOs/CTLs

Collaborate with CMC team, QA and CMOs /CTLs towards timely generation and approval of documents

Communicate scientific results (oral and written) in a clear and concise manner within cross-functional teams

Author technical reports and documents in support of regulatory filing

Assist in preparation of CMC documents for regulatory submissions (IND, IMPD, and/or NDA)

THE IDEAL CANDIDATE

BS/ MS in chemistry or pharmaceutical sciences with 5 + years of experience in analytical development

Experience with analytical techniques for small drug molecules and oral solid formulations required , including UPLC/HPLC, LC-MS, KF, dissolution testing, IR, particle size analysis, and solid-state characterization techniques

Proven track record in applying analytical techniques to solve challenging problems

Experience in working with CMOs and CTLs

Experience in early to late-stage drug development

Strong organizational and communication skills

Comfortable in a fast-paced small company environment and a strong team player

Experience and k nowledge in ICH, cGMP and regulatory requirements

This position is located in South San Francisco, CA. We are not considering fully remote applicants.

The salary range for this position is $112,000 USD to $135,000 USD annually. This salary range is an estimate, and the actual salary may vary based on the Company’s compensation practices.

Alumis Inc. is an equal opportunity employer.

Alumis compensation packages include generous stock option grants for all employees as well as an annual bonus program.

Other benefits include:

Health insurance premiums paid at 90% for employee, 80% for dependents

Free access to Genentech Bus & Ferry Share program

$100 monthly cell phone stipend

Unlimited PTO for Exempt employees

Free onsite gym and a kitchen stocked with yummy snacks and drinks!

We are a hard-working, collaborative team on a mission to transform patient’s lives-- and we aspire to elevate , challenge and nurture one another along the way.

Alumis Inc. is an equal opportunity employer.