Director, Commercial Excellence

About Summit:

Summit Therapeutics Inc. is a biopharmaceutical oncology company with a mission focused on improving quality of life, increasing potential duration of life, and resolving serious unmet medical needs. At Summit, we believe in building a team of world class professionals who are passionate about this mission, and it is our people who drive this mission to reality. Summit’s core values include integrity, passion for excellence, purposeful urgency, collaboration, and our commitment to people. Our employees are truly the heart and soul of our culture, and they are invaluable in shaping our journey toward excellence.

Summit’s team is inspired to touch and help change lives through Summit’s clinical studies in the field of oncology. Summit has multiple global Phase 3 clinical studies, including:

Non-small Cell Lung Cancer (NSCLC)

HARMONi: Phase 3 clinical study which was intended to evaluate ivonescimab combined with chemotherapy compared to placebo plus chemotherapy in patients with EGFR-mutated, locally advanced or metastatic non-squamous NSCLC who were previously treated with a 3rd generation EGFR TKI.

HARMONi-3: Phase 3 clinical study which is intended to evaluate ivonescimab combined with chemotherapy compared to pembrolizumab combined with chemotherapy in patients with first-line metastatic NSCLC.

HARMONi-7: Phase 3 clinical study which is intended to evaluate ivonescimab monotherapy compared to pembrolizumab monotherapy in patients with first-line metastatic NSCLC.

Colorectal Cancer (CRC)

HARMONi-GI3: Phase 3 clinical study intended to evaluate ivonescimab in combination with chemotherapy compared with bevacizumab plus chemotherapy.

Ivonescimab is an investigational therapy not presently approved by any regulatory authority other than China’s National Medical Products Administration (NMPA). Summit is headquartered in Miami, Florida, and has additional offices in California, New Jersey, the UK, and Ireland.

Overview of Role:

The Director, Commercial Excellence is a headquarters-based role within Summit Therapeutics Commercial Operations. This role owns the governance and execution layer of the Commercial Excellence function — incentive compensation administration, territory design and change management, CRM configuration and administration, targeting and segmentation methodology, field reporting standards, and the national KPI framework. The Director reports to the Senior Director, Commercial Excellence and is the day-to-day operational counterpart to Marketing, Market Access, and Medical Affairs Operations, and Market Research ensuring every function operates from a consistent, compliant, and well-governed infrastructure. This is a role for someone who thrives on building from scratch, can manage multiple workstreams simultaneously, and understands that operational excellence in oncology commercial launch is the foundation that makes field execution possible.

Role and Responsibilities:

Own incentive compensation design and administration — plan design, quota setting, goal crediting, dispute resolution, and payment accuracy across the full field organization

Own territory design and alignment — build and maintain the territory structure, manage alignment changes through a defined change governance process, and ensure roster accuracy at all times

Own CRM configuration and administration — partner with IT and the Director of Commercial Data and Technology to configure, maintain, and continuously improve the CRM; own business requirements, user access, and data quality

Own targeting and segmentation methodology — define and maintain the HCP and HCO targeting approach, manage decile assignments, and ensure targeting outputs are operationalized in the CRM and field tools

Define and govern national KPI standards — establish field reporting definitions, maintain the national KPI framework, and ensure consistent measurement across all geographies

Serve as the operational counterpart to Marketing, Market Access, and Medical Affairs Operations — own the day-to-day working relationship with each function, ensure aligned processes, and resolve operational conflicts before they reach the field

Support Finance and Compliance on process governance, audit readiness, PDRP compliance, and Sunshine Act reporting requirements

Own roster management, sales crediting, and goal setting administration — maintain accurate headcount data, manage new hire and termination checklists, and ensure crediting rules are applied correctly

Partner with the Field Excellence team to ensure operational infrastructure is correctly translated into field-level intelligence — own the systems and processes that Field Excellence draws on to serve each sales leader

All other duties as assigned

Experience, Education and Specialized Knowledge and Skills:

Bachelor's degree required; advanced degree in business, life sciences, or a related field preferred

Minimum of 10+ years of relevant experience in the life sciences industry

Minimum 5+ years of experience in pharmaceutical or biotech commercial operations, with direct ownership of incentive compensation, territory alignment, or CRM administration

Oncology experience strongly preferred; buy-and-bill and biomarker-driven specialty experience a plus

Launch experience required — must have experience building or inheriting a commercial operations infrastructure during a product launch, not simply maintaining a running system

Deep working knowledge of Veeva CRM or equivalent; familiarity with IC administration platforms (Xactly, NICE/Varicent, or similar) required

Strong cross-functional collaboration skills — this role works daily with Marketing, Market Access, Market Research, Medical Affairs Operations, Finance, Compliance, and the Field Excellence team; the ability to resolve competing priorities without escalation is essential

High attention to detail and comfort with data — IC errors and territory misalignments have direct compliance, payroll, and field morale consequences; precision is not optional in this role

Travel up to 20% — primarily for national meetings, POA preparation, and field alignment activities

This is the pay for this position

Pay Transparency

$203,000 — $253,000 USD

Actual compensation packages are based on several factors that are unique to each candidate, including but not limited to skill set, depth of experience, certifications, and specific work location. This may be different in other locations due to differences in the cost of labor. The total compensation package for this position may also include bonus, stock, benefits and/or other applicable variable compensation.

Summit does not accept referrals from employment businesses and/or employment agencies in respect of the vacancies posted on this site. All employment businesses/agencies are required to contact Summit’s Talent Acquisition team at [email protected] to obtain prior written authorization before referring any candidates to Summit.

Summit Therapeutics Inc. is an Equal Opportunity Employer and takes pride in creating and maintaining diverse environment. We do not discriminate in recruitment, hiring, training or promotion or any other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, marital or veteran status, disability, or any other legally protected status.