Program Manager, Preclinical Programs

Who We Are:

Neurocrine Biosciences is a leading biopharmaceutical company with a simple purpose: to relieve suffering for people with great needs. We are dedicated to discovering, developing and commercializing life-changing treatments for patients with under-addressed neurological, psychiatric, endocrine and immunological disorders. The company's diverse portfolio includes FDA-approved treatments for tardive dyskinesia, chorea associated with Huntington's disease, classic congenital adrenal hyperplasia, hyperphagia in Prader-Willi syndrome, endometriosis* and uterine fibroids*, as well as a robust pipeline including multiple compounds in mid- to late-phase clinical development across our core therapeutic areas. For more than three decades, we have applied our unique insight into neuroscience and the interconnections between brain and body systems to treat complex conditions. We relentlessly pursue medicines to ease the burden of debilitating diseases and disorders, because you deserve brave science. For more information, visit neurocrine.com , and follow the company on LinkedIn , X , Facebook and YouTube . ( *in collaboration with AbbVie )

At Neurocrine, strong leadership drives both business results and team success. We look for leaders who think strategically, anticipate what’s ahead and set clear direction, while building and empowering high-performing teams. Successful leaders foster an environment where people are motivated to do their best work and deliver meaningful, measurable impact through sound decision-making and accountability.



About the Role:

The Program Manager role supports the planning, execution, and operational effectiveness of Preclinical programs and initiatives. Provides program management leadership across multiple Preclinical functional sub teams, partnering with scientific and functional leads to translate cross-functional program strategies into integrated plans and coordinated execution spanning early research through Development Candidate selection, IND/CTA readiness, and First-in-Human development.

The Program Manager partners closely with subject matter experts across Toxicology, DMPK/ADME, Bioanalytical Sciences, Clinical Pharmacology, Clinical Pharmacology Bioanalytical, and Pharmacometrics, and interacts with stakeholders across Research, CMC, Clinical Development, Regulatory Affairs, Finance, and Program Management to facilitate alignment on program strategy, milestones, risks, timelines, resources, and critical-path activities.

The role also supports broader early-development portfolio visibility, ensuring that emerging program information, risks, dependencies, and decisions are appropriately communicated across functional, asset, portfolio, and leadership governance forums. _

Your Contributions (include, but are not limited to):

Provides program management leadership for 6 or more Preclinical functional sub teams representing defined segments of the preclinical portfolio and partners with scientific leads and subject matter experts to coordinate execution across multiple assets and development stages

Facilitates team alignment and execution against integrated program plans, including management of key milestones, dependencies, risks/issues, critical-path activities, budgets, resources, and governance requirements from early development through IND/CTA and FIH readiness

Partners with subject matter experts across Toxicology, DMPK/ADME, Bioanalytical, Clinical Pharmacology, Clinical Pharmacology Bioanalytical, and Pharmacometrics to integrate functional plans, identify cross-disciplinary dependencies, and proactively surface risks or decisions that may affect program timelines

Develops and maintains integrated project plans, timelines, risk and action trackers, meeting documentation, dashboards, and program status updates. Monitors program performance and facilitates issue resolution and appropriate escalation to maintain progress toward development objectives

Supports preparation for key portfolio and development milestones, including Portfolio Entry, Development Candidate selection, IND/CTA readiness, and First-in-Human activities, ensuring appropriate functional planning and visibility ahead of major decision points

Partners with the designated Preclinical Representative to support effective representation of the integrated Preclinical perspective within cross-functional Asset/Core Teams, ensuring that relevant scientific considerations, functional risks, dependencies, and recommendations are appropriately aligned and communicated

Partners with Cross-Functional Program Management, CMC Functional Program Management, Regulatory Affairs, and other stakeholders to ensure that asset-level strategic decisions are effectively translated into coordinated functional execution and that emerging Preclinical risks and dependencies are appropriately communicated into broader asset governance

Supports IND Operations and regulatory readiness activities, including tracking of critical Preclinical reports and deliverables, cross-functional dependencies, submission timelines, and other activities required to support IND/CTA submissions

Supports portfolio-level tracking and communications, including dashboards, portfolio updates, milestone tracking, and leadership reporting to provide timely visibility into early-development program progress, emerging risks, and upcoming decisions

Partners with Finance and functional stakeholders to support long-range planning, annual budgeting, forecasting, and financial tracking for Preclinical program activities and external development spend

Identifies opportunities to improve processes, workflows, governance, information flow, and team effectiveness and recommends and contributes to continuous-improvement initiatives that enhance execution and collaboration across R&D

Assists with adoption and optimization of new systems, tools, dashboards, and digital capabilities that improve portfolio visibility, program management, knowledge management, and R&D operational effectiveness

Builds collaborative relationships across Research, Preclinical, CMC, Clinical Development, Regulatory Affairs, Finance, Portfolio Management, and Cross-Functional Program Management to support effective coordination and progression of programs through the development lifecycle

Requirements:

6+ years of applicable experience AND Bachelor’s degree OR

4+ years of applicable experience AND Master’s degree OR

2+ years of applicable experience AND PharmD, or PhD

Working knowledge of drug discovery and development processes spanning early research, Development Candidate selection, IND/CTA readiness, and First-in-Human development

Understanding of Preclinical & Clinical Pharmacology disciplines and their role in integrated drug development, including Toxicology, DMPK/ADME, Bioanalytical Sciences, Clinical Pharmacology, Clinical Pharmacology Bioanalytical, and Pharmacometrics

Ability to integrate plans, milestones, dependencies, risks, and deliverables across multiple PCCP disciplines and development programs

Understanding of the cross-functional dependencies among PCCP, Research, CMC, Clinical Development, Regulatory Affairs, and other development functions

Knowledge of key preclinical and early clinical development milestones and the planning and operational activities required to support progression through major program decision points

Familiarity with IND/CTA readiness and submission activities, including coordination and tracking of functional reports, data, documentation, dependencies, and timelines supporting regulatory submissions

Ability to partner effectively with scientific and functional subject-matter experts and translate complex scientific and technical activities into integrated program plans, milestones, risks, and execution priorities

Ability to identify and communicate scientific and operational dependencies,