Quality Management System Lead

Company Overview

Tango Therapeutics is a biotechnology company dedicated to discovering novel drug targets and delivering the next generation of precision medicine for the treatment of cancer.

Using an approach that starts and ends with patients, Tango leverages the genetic principle of synthetic lethality to discover and develop therapies that take aim at critical targets in cancer.

This includes expanding the universe of precision oncology targets into novel areas such as tumor suppressor gene loss and their contribution to the ability of cancer cells to evade immune cell killing.

The Tango labs and offices are located at 201 Brookline Avenue, in the Fenway area of Boston, Massachusetts.

Summary

Own and continuously improve the QMS framework to ensure processes, document control, training, and quality records support consistent compliance across functions and regions.

Your Role:

Define and maintain QMS structure: policies, SOPs, work instructions, templates, and governance

Ensure harmonization across GxP domains (GMP/GLP/GCP) and alignment with applicable regulations/standards

Oversee document lifecycle management (authoring standards, review/approval, periodic review, archival)

Ensure change control processes exist and are followed (QMS changes and cross-functional change impacts)

Oversee GxP training framework (curricula, assignment rules, effectiveness checks, compliance reporting)

Partner with functional owners to define role-based training requirements

Ensure QMS records are complete, traceable, audit-ready, and meet data integrity principles

Establish metrics and trending for QMS health (cycle time, overdue items, training compliance)

Lead QMS simplification/optimization, including CAPA prevention initiatives based on trending and learnings

Prepare Quality Management Review packages: KPIs, risks, audit outcomes, CAPA effectiveness, and improvement plans

What You Bring:

Bachelor’s degree in Life Sciences, Quality, or related discipline (required)

Quality-related certification preferred (e.g., ASQ, ISO Lead Auditor, Quality Systems)

Training in electronic QMS platforms advantageous

8–12 years in Quality Assurance or Compliance

Hands-on experience managing QMS in regulated GxP environments

Experience supporting QMS-related inspections and audits

QMS design, lifecycle management, and governance

GxP training systems and compliance tracking

Data integrity and document control standards

Process‑oriented, structured, and detail focused

Strong communication and training skills

Ability to simplify complex processes and drive alignment

We are an equal opportunity employer and value diversity at our company. We do not discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status.

Salary range

$151,200 — $226,800 USD