Sr Director, National Accounts

Definium Therapeutics is a late-stage clinical biopharmaceutical company and our mission is to forge a new era of psychiatry by applying scientific rigor to psychedelics, with the goal of developing accessible treatments that unlock healing at scale.

Our lead product candidate, lysergide tartrate (our proprietary orally disintegrating tablet form of lysergide (LSD) D-tartrate), represents a highly differentiated, potential best-in-class opportunity for patients suffering from generalized anxiety, major depressive disorder, and posttraumatic stress disorder. Our early stage pipeline includes DT402, the R-enantiomer of MDMA and is under development to target the core symptoms of autism spectrum disorder (ASD), specifically addressing social communication challenges.

Guided by the recognition that patients deserve more than better, Definium is relentlessly advancing a new generation of therapeutics intended to address the underlying causes of psychiatric and neurological disorders. By turning evidence into impact, Definium aims to change the trajectory of today’s mental health care crisis and enable a healthier future. Headquartered in New York, Definium Therapeutics trades on Nasdaq under the symbol DFTX.

Together we are moving psychiatry forward—beyond better, into a boundless future. Join us!

The Senior Director, National Accounts implements Definium’s market access strategy across assigned commercial payer and PBM accounts and develops account-specific recommendations to support patient access and reimbursement. This role focuses on commercial national accounts and excludes Medicaid and other government accounts.

Primary Responsibilities

Implement approved market access strategies and develop customer-specific access and reimbursement recommendations

Own executive relationships with assigned PBMs, national commercial health plans, and other key market access stakeholders

Lead account planning, customer engagement, and business reviews for assigned accounts

Engage payer pharmacy, medical, clinical, policy, and reimbursement stakeholders

Partner cross-functionally to support payer access planning, reimbursement strategy, and customer-specific implementation needs

Translate approved clinical, outcomes, and economic evidence into payer-relevant discussions

Generate customer insights and market intelligence to support account planning, launch readiness, and leadership decision-making

Monitor payer trends, benefit design, formulary and medical policy processes, utilization management, behavioral health management, reimbursement dynamics, and competitive activity

Primary Customers

National PBMs

National commercial health plans

National integrated delivery systems

Required Qualifications

Bachelor's degree required; advanced degree preferred

Minimum 10 years of market access, payer, reimbursement, account management, or related biopharmaceutical experience

Demonstrated experience with national commercial health plans, PBMs, and/or large regional payer accounts

Experience in CNS, psychiatry, mental health, behavioral health, or other specialty product launches preferred

Track record implementing market access strategies and achieving account-specific access objectives

Understanding of payer policy, reimbursement, benefit design, formulary management, and coverage decision-making

Working knowledge of formulary review, medical policy development, prior authorization, step therapy, and medical versus pharmacy benefit considerations

Experience translating clinical, HEOR, outcomes, and value evidence into customer-relevant discussions

Experience engaging payer decision-makers, including P&T committees or similar clinical, pharmacy, medical policy, and value assessment forums

Strong executive relationship management skills with payer and PBM stakeholders

Cross-functional collaboration with Medical Affairs, HEOR, Commercial Operations, Patient Services, and Legal/Compliance

Ability to generate actionable customer insights and market intelligence

Willingness to travel, typically 50%+

Knowledge of relevant compliance requirements and payer communication standards

Compliance and PIE-Aligned Communications

Payer communications, including appropriate pre-approval information exchange and healthcare economic information, will be conducted in alignment with approved company materials, Medical/Legal/Regulatory review processes, applicable FDA guidance, PIE guidelines, and company compliance policies. This role will partner closely with internal stakeholders to ensure payer planning discussions are accurate, consistent, and appropriately aligned with approved access, value, and launch readiness objectives.

The starting base pay range for this position is $220,000.00 - $280,000.00. Compensation will be determined based on several factors including, but not limited to, skill set, years of experience, and the employee’s geographic location.

Employees in this role may be entitled to additional compensation, including bonus and equity. Benefits information is listed on our Jobs Page. The Company provides competitive benefits to employees including:

100% paid health benefits including Medical, Dental and Vision for you and your dependents

401(k) program with company match and vesting after the turn of the first month after your start date

Flexible time off

Generous parental leave and some fun fringe perks!