Vice President, Supply Chain

Description

Role Title: Vice President, Supply Chain

Location: Remote, USA

Status: Full-Time Exempt

Department: CMC

Enliven Therapeutics is a clinical-stage biopharmaceutical company focused on the discovery and development of small molecule inhibitors to help people with cancer not only live longer, but live better. The Company aims to address existing and emerging unmet needs with a precision medicine approach that improves survival and enhances overall well-being. Its discovery process combines deep insights in clinically validated biological targets and differentiated chemistry with the goal of designing therapies for unmet needs.

Role Summary

The Vice President, Supply Chain will own Enliven’s global supply chain strategy while preparing the company for late-stage development, regulatory approval, and commercial supply.

This leader will ensure uninterrupted supply of investigational product across Enliven’s clinical programs and coordinate closely with CMC, Clinical Operations, Quality, Regulatory, Commercial, Finance, and other functions. The role requires someone who can set strategy while remaining actively involved in forecasting, planning, logistics, vendor oversight, risk management, and issue resolution.

A key mandate is to anticipate potential supply gaps and ensure that manufacturing, packaging, labeling, release, inventory, or logistics issues do not disrupt clinical development or future commercial supply. The successful candidate will bring direct experience moving products from clinical development into commercial operations and supporting at least one pharmaceutical product launch.

Key Responsibilities

Clinical Supply Leadership

• •Lead global clinical supply strategy and execution across Enliven’s portfolio, ensuring uninterrupted supply for current and future clinical trials.
• •Translate clinical protocols, enrollment assumptions, development plans, and manufacturing schedules into demand forecasts, supply plans, inventory strategies, and budgets.
• •Provide hands-on oversight of forecasting, production planning, packaging, labeling, distribution, inventory management, logistics, returns, reconciliation, and destruction.
• •Coordinate internally across Clinical Operations, CMC, Quality, and Regulatory to align manufacturing, release, packaging, and distribution activities with program and study timelines.
• •Oversee global logistics, including import/export activities, customs documentation, depot strategy, and country-specific labeling and distribution requirements.
• •Establish appropriate inventory and safety-stock strategies, balancing continuity of supply, shelf life, cost, and program risk.
• •Proactively identify potential supply gaps, capacity constraints, and logistics challenges; develop scenarios, contingencies, and mitigation plans.
• •Lead cross-functional resolution of supply disruptions and other unplanned events affecting clinical timelines or patient supply.
• •Oversee IRT-related supply strategy and execution and comparator sourcing, as applicable.
• •Support relevant clinical and regulatory documentation, submissions, inspections, and audit-readiness activities.

Late-Stage and Commercial Supply Readiness

• •Develop and execute the roadmap for transitioning Enliven from a clinical-stage supply model to a scalable commercial supply chain.
• •Establish fit-for-purpose processes, systems, governance, and external partnerships for late-stage development, launch, and ongoing commercial supply.
• •Lead commercial supply and launch-readiness planning, including demand and supply planning, inventory strategy, packaging and labeling, serialization, distribution, logistics, 3PL strategy, and product traceability.
• •Partner with Commercial and Finance on integrated forecasting, demand planning, and S&OP/IBP capabilities appropriate to the company’s stage.
• •Ensure commercial supply requirements are incorporated early into manufacturing, packaging, regulatory, distribution, and lifecycle strategies.
• •Develop launch scenarios and contingency plans addressing regulatory timing, demand uncertainty, manufacturing capacity, release timing, inventory, and market uptake.
• •Help ensure a seamless transition from clinical to commercial supply without operational or logistical gaps.

External Supply Network and Operational Execution

• •Oversee Enliven’s external supply network, including CMOs/CDMOs, packaging and labeling providers, depots, logistics providers, and 3PLs.
• •Lead vendor evaluation, selection, contracting, onboarding, governance, and performance management, including RFPs and SOWs.
• •Partner with CMC and Quality to ensure external partners can meet evolving clinical, registrational, and commercial requirements.
• •Develop sourcing, contracting, capacity-planning, and business-continuity strategies for critical supply activities.
• •Maintain clear visibility into inventory, supply status, assumptions, risks, budgets, and key decisions, providing timely updates to senior leadership.
• •Develop scalable SOPs, planning processes, systems, and performance metrics that improve supply visibility, reliability, and execution.
• •Serve as the supply-chain subject-matter expert during audits and inspections, as appropriate.

Cross-Functional and Hands-On Leadership

• •Serve as Enliven’s senior supply-chain leader while remaining actively engaged in day-to-day planning, execution, problem-solving, and decision-making.
• •Coordinate closely with CMC, Clinical Operations, Quality, Regulatory, Commercial, Finance, Legal, and other departments to maintain alignment and resolve dependencies.
• •Represent Supply Chain and, when appropriate, CMC or Technical Operations in program teams, governance forums, and leadership discussions.
• •Clearly communicate supply strategy, readiness, risks, tradeoffs, and investment requirements to executive leadership.
• •Provide practical direction and support to supply-chain team members while fostering accountability, collaboration, and proactive risk management.

Requirements

Required

• •Bachelor’s degree in supply chain, engineering, life sciences, business, or a related field; advanced degree preferred.
• •Approximately 15 or more years of progressively responsible pharmaceutical or biotechnology supply-chain experience.
• •Deep, hands-on experience leading global clinical supply, including forecasting, inventory management, packaging and labeling, distribution, logistics, and external-partner oversight.
• •Experience leading supply chain for pivotal/Phase 3 clinical development and transitioning products from clinical-stage operations through commercial readiness.
• •Firsthand experience establishing commercial supply-chain capabilities and playing a supply chain leadership role in at least one pharmaceutical product launch, including supporting NDA readiness and pre-approval inspections.
• •Strong knowledge of clinical and commercial supply requirements, including demand planning, inventory strategy, packaging and labeling, serialization, distribution, 3PL management, and product traceability.
• •Experience managing CMOs/CDMOs and other outsourced supply partners within a virtual or highly outsourced biotechnology model.
• •Experience building and leading supply chain organizations, including planning internal staffing, consultant support and outsourced capabilities.
• •Strong understanding of GMP, GDP, and applicable global clinical-supply requirements.
• •Experience leading or materially participating in ERP/planning/inventory management/supply visibility systems implementation.
• •Demonstrated ability to anticipate supply gaps, build practical contingency plans, and resolve disruptions quickly.
• •Ability to work effectively at both strategic and tactical levels in a small or mid-sized biotechnology company.
• •Strong cross-functional leadership, communication, financial judgment, negotiation, and problem-solving skills.
• •Ability to manage multiple priorities and make sound decisions in a fast-paced, evolvi