Associate Scientist, Automation

About Stylus Medicine:

Stylus Medicine is developing transformative in vivo genetic medicines to unlock cures. Stylus combines engineered recombinases with non-viral delivery to specifically encode therapeutics. The company’s approach is versatile and modular, with potential therapeutic application across oncology, autoimmune, genetic diseases, and beyond.

About the Role:

Stylus Medicine is seeking an Associate Scientist, Automation to join our Genome Sciences & Engineering team and build automation capabilities that accelerate the development of our next-generation gene editing tools. This role is ideal for a collaborative, organized, and creative scientist who thrives in a fast-paced environment and enjoys tackling complex problems to expand the frontiers of genome editing. This individual will play a key role in discovery and engineering efforts, advancing recombinase-based genome editing platforms and collaborating across diverse R&D teams.

Key Responsibilities & Accountabilities:

Develop automation capabilities that support reagent generation and high-throughput (HT) screening workflows

Optimize automated HT workflows for plasmid cloning and RNA generation via in vitro transcription (IVT)

Develop and run QC assays to sequence-verify plasmid constructs and assess the integrity of IVT products

Partner with screening scientists to automate plate preparation, reagent dispensing, and assay setup for cell-based HT screens

Coordinate DNA synthesis and reagent orders with external vendors

Manage raw material, plasmid, and RNA inventories

Maintain detailed documentation of protocols, methods, and results in electronic lab notebooks

Present findings clearly to other teams and contribute to scientific discussions and decision-making

Qualifications & Skills:

BS with 5+ years or MS with 2+ years of full-time industry or academic research experience in life sciences, biology, biochemistry, engineering, or a related field

Experience with automated liquid handling systems (e.g., Biomek, Mantis, Echo) and high-throughput laboratory workflows, including method development and troubleshooting

Familiarity with automating cell-based screening workflows; experience with flow cytometry is a plus

Proficiency in nucleic acid QC methods, including TapeStation, Qubit, NanoDrop, and qPCR

Hands-on molecular biology experience, including cloning and RNA production and purification

Working knowledge of data analysis and information management tools such as Excel, GraphPad Prism, SnapGene, and Benchling

Experience with laboratory inventory management

Track record of generating precise, reproducible data and performing rigorous quantitative analysis

Clear and approachable communication skills, with the ability to present technical information clearly and concisely to diverse audiences

Exceptionally organized and comfortable managing large sample sets, inventories, and overlapping projects

Strategic thinker who effectively plans and prioritizes to maximize scientific impact

Collaborative mindset with a team-first attitude

Resourceful problem-solver who enjoys troubleshooting instruments and workflows and thrives amid scientific uncertainty

Pay Range: $105,000 - $120,000