Director, Commercial Excellence

Location: This position may be performed remotely but requires flexibility and a willingness to travel as needed.

Position Summary

The Director, Commercial Excellence leads end-to-end operation of the brand’s commercial model, ensuring strategy, workflows, systems, people, and data work together to support effective execution. You will set the standard for how the commercial organization operates, continually monitor and challenge the brand’s operating model and strategic assumptions, make evidence-based recommendations, and partner with senior leaders across Commercial, Medical Affairs, Market Access, Trade & Distribution, and Finance to improve results, acting with urgency whenever brand performance is at risk.

Primary Responsibilities

Own end-to-end operations for the brand. Lead the design and completion of the commercial build and serve as the organization’s authority on the strategy, workflows, systems, vendors, and data that support the brand. Define and lead the vision for commercial excellence.

Drive operational performance — Define and own the integrated view of how the brand operates, tracking performance against goals and surfacing risks before they escalate.

Diagnose and resolve cross-functional issues — Partner with senior functional leaders, up to and including the leadership team, to align on priorities, identify issues and root causes, and drive timely resolution, sharing accountability for outcomes and acting with urgency when commercial performance is at risk.

Challenge and improve the operating model — Continuously question strategic assumptions and existing processes, using evidence-based analysis to recommend improvements that strengthen commercial performance. Present recommendations directly to leadership team.

Shape strategy through business insights— Lead the research and intelligence agenda in partnership with cross-functional leaders, translating market dynamics, competitor activity, and emerging trends into actionable recommendations that inform strategic decisions and strengthen commercial performance.

Lead without authority at scale – Direct the work of matrixed, cross-functional teams and external vendors on the highest-impact commercial initiatives, such as launch readiness and operating-model redesign, without formal direct reports.

Qualifications and Key Success Factors

Bachelor's degree required; with extensive experience in pharma/biotech commercial operations, brand management, consulting, or related commercial/strategic roles

Recognized expertise in how commercial strategy, data, systems, workflows, and vendors come together to drive brand performance across a commercial portfolio

Strategic, analytical problem solver who sees across functions, brings clarity to complex issues, identifies root causes, and translates evidence into actionable recommendations—following through until issues are resolved. High ownership and urgency; steps into ambiguity, challenges assumptions, and acts when performance is at risk

Credible, collaborative influencer who can align and challenge executive and senior cross-functional leaders, including the leadership team, without relying on authority

Curious, resilient, and constantly looking for a better way to operate and deliver results

The physical and mental requirements of our roles include but are not limited to regular use of a computer, devices or other office equipment, clear communication, and occasional movement. You'll need comfort with screen work, basic hand coordination, and focus. Reasonable accommodations may be made to enable individuals with disabilities to perform these functions.

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Annualized Base Salary

$215,000 — $240,000 USD

Compensation & Benefits

At Praxis, we believe that taking care of our people (and their people) is important, so we provide a world class benefits package to help you thrive. This includes 99% of the premium paid for medical, dental and vision plans. We also provide company-paid life insurance, AD&D, disability benefits, and voluntary plans to personalize your coverage. Thinking about the future? We match dollar-for-dollar up to 6% on eligible 401(k) contributions and sweeten the deal with long-term stock incentives and ESPP. We provide a discretionary quarterly bonus, an extremely flexible wellness benefit, generous PTO, paid holidays and company-wide shutdowns. Not to mention, you'll also be joining a phenomenal crew of colleagues who are smart, engaged and inspiring. We aim high, collaborate hard, and produce results. Let’s achieve the impossible together!

Company Overview

Praxis Precision Medicines is a clinical-stage biopharmaceutical company translating genetic insights into the development of therapies for central nervous system disorders characterized by neuronal imbalance. At Praxis we share a common vision of reshaping the human condition into a more freeing and fulfilled existence by developing high impact medicines for patients and families affected by and living with complex brain disorders. Our core Values of Trust , Ownership , Curiosity and Results are foundational to every aspect of our business and are exemplified by each and every one of our team members.

• Diversity, Equity & Inclusion
• Guided by our core values, at Praxis Precision Medicines, Inc. we continue to DARE FOR MORE ® to advance, promote, and champion diversity, equity, and inclusion by encouraging individuals to bring their authentic selves and perspectives to work each day. We are an equal opportunity employer and committed to providing opportunities to all qualified applicants without regard to race, religious creed, color, gender identity or expression, age, national origin, sexual orientation, disability, genetics, military service and veteran status, or any other characteristic protected by federal, state, or local laws.

• Attention: Job Scam Alert
• Praxis has recently become aware of fraudulent job recruitment postings from individuals claiming to represent Praxis. These postings seek financial information in connection with fraudulent opportunities for employment. If you suspect any fraudulent activity or misrepresentation in connection with a Praxis job opportunity, please report it to [email protected] .

Praxis does not accept unsolicited submissions from recruitment agencies for open positions. We ask all recruitment agencies to refrain from contacting any Praxis employee regarding any position. All unsolicited resumes submitted by recruitment agencies to any Praxis employee in any form or method will be deemed to be the property of Praxis, and Praxis explicitly reserves the right to hire those candidate(s) without any financial obligation to the recruitment agency.