Open-Rank Tenure-Track Faculty of Anesthesiology

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Job Title:

Open-Rank Tenure-Track Faculty of Anesthesiology

Department:

Medicine | Anesthesiology

Tenure faculty (regardless of rank) - persons with the titles of professor, associate professor, assistant professor and instructor who serve on appointments totaling 50% or more service to the university and who are eligible for tenure or who have obtained tenure. Duties and responsibilities are assigned in accordance with the workload guidelines laid out in the pattern of administration of each faculty member’s tenure initiation unit (TIU) and, as appropriate, regional campus; obligations will include research, service and/or teaching or clinical practice. These faculty will have earned doctorate or other terminal degree in the relevant field of study or possession of equivalent experience.

Additional Information:

Open Faculty Search for Tenure Track Faculty with a PhD or MD/DO (Assistant Professor, Associate Professor or Professor) in Perioperative Health Care Research in Anesthesiology, Neuroscience, Pain and Addiction

Position Overview

The Department of Anesthesiology at Wexner Medical Center/The Ohio State University College of Medicine is initiating a search for one (or more) Tenure Track faculty position in Basic , Translational and/or Clinical Research . To accelerate our research growth, we have recently recruited 2 NIH funded tenure track faculty and we plan to recruit additional faculty in strategic areas of research to complement our existing strengths and grow our capabilities. We encourage applicants to apply for Assistant, Associate or a Full Professor position. Qualified candidates for the Tenure Track will be focused on research relevant to perioperative care and anesthesiology, in subspecialty areas generally focused on Neuroscience, Pain and Addiction . Applications in other research areas may be considered and should complement ongoing research areas outlined below. Specific target areas of investigation could include, but are not limited to, neuromodulation, neuroimmune regulation, neuroinflammation and reactive glia, in the context of perioperative neural dysfunction, neuroprotection, pain signaling and analgesia, recovery and wound healing, or addiction research. Candidates focused on Women’s Health in the specific target areas are encouraged to apply. We are interested in recruiting either PhD or Physician scientists.

Successful applicants will join a growing and dynamic research environment dedicated to translating innovative laboratory discoveries in basic mechanisms to human studies and clinical trials with a long-term goal to improve patients’ lives. We have an emerging program on ischemic spinal cord injury following TAAA surgery to repair an aneurysm ( targeting open surgical repair versus TEVAR’ ), postsurgical delirium, neuromodulation and neuroprotection and perioperative pain management. One of our Tenured Professors is part of a recently funded NIH Blueprint Medtech Award in 2025 in collaboration with CoolSpine LLC (sponsored by NINDS & National Institute of biomedical Imaging and Bioengineering) through a U54 grant mechanism. He will work with his collaborators on an innovative project titled "Intrathecal Cooling Catheter to Provide Neuroprotection to Avoid Paraplegia Resulting from Open and Endovascular Thoracic Aneurysm Repair" ( https://blueprintneurotech.org/awardees/ ). We recently hosted the first international NIH R13 sponsored conference on strategies to combat ‘paraplegia after ischemic spinal cord injury in patients undergoing TAAA surgery. We also hosted an international conference sponsored by NIH to develop consensus guidelines for preventing opioid induced respiratory depression (OIRD).

Our established NIH R01funded program in basic, translational and clinical research is focused on pathogenic mechanisms of postoperative ileus and POGD that costs billions in healthcare costs due to extended hospitalizations, complications and re-admissions. New or ongoing NIH R01 funded studies are investigating ‘Enteric neuropathy’, surgical trauma and mechanical stress induced Postoperative ileus’ (POI), and ‘GPCRs in neuroinflammation and POI. We are interested in developing novel therapeutic targets in postsurgical ileus (i.e. for neuroinflammation associated with glia, neurons and immune cells, purinergic signaling, ‘reactive glia’, Ca2+neuroimaging , patch clamp recordings, neuroplasticity , alterations in neural circuit behavior, programmed cell death and ferroptosis ). Our efforts are complemented by further development of enhanced recovery after surgery (ERAS) protocols that is a College of Medicine priority The Medical Director of ERAS protocols in the College of Medicine is a physician scientist in our department who implemented over 20 ERAS protocols to date. TheChair of the department is the President of ERAS USA. Tremendous opportunities exist for research and RCTs. A funded multi-institutional Patient Center Outcomes Research Institute (PCORI) grant is investigating new therapeutic strategies to reduce or prevent postoperative delirium, POCD and provide neuroprotection in elderly patients.

An ongoing 5-year FDA/P50 consortium grant between OSU Department of Anesthesiology and Nationwide Children’s Hospital seeks to accelerate implementation of pediatric devices into clinical practice. A multi-center NIH (NHLBI) SBIR grants is focused on “Advanced Prediction of Emerging Respiratory Decline with the Linshom Continuous Predictive Respiratory Sensor (CPRS)”. Recently, we recruited the first NIH-R01 funded woman scientist from the Magee Women’s Institute, with a track record of NIH funding as PI on women’s postsurgical recovery, immune cell dysregulation and wound healing in women with diabetes. We also recruited an NIH funded Tenured Professor of Anesthesiology, with a focus on neurotoxicity to anesthetics following neonatal exposure and mitochondrial dysfunction. Her research program is at the intersection of neuroscience, stem cell biology, and mitochondrial medicine. Dr. Bai’s research centers on elucidating mitochondrial, non-coding RNA, and redox-mediated mechanisms underlying anesthetic- and alcohol-induced neurotoxicity using human stem cell– based systems and complementary animal models. A central contribution of her program has been the development and application of human induced pluripotent stem cell (hiPSC)-derived models, particularly three-dimensional cerebral organoids (mini brains) as t