PhD Candidate in Translational Pancreatitis and Thromboinflammation Research; part time 65 (m/w/d)

Scope of duties

• · Work on the Collaborative Research Centre project (SFB) “Thromboinflammatory mechanisms of pancreatitis progression and associated splanchnic and portal vein thrombosis”
• · Investigate cellular and molecular mechanisms that link pancreatic inflammation, coagulation and thrombotic complications
• · Study the role of platelet–neutrophil interactions and sphingolipid metabolism in acute and acute-on-chronic pancreatitis
• · Plan and perform experimental studies using cellular systems, patient-derived biosamples and established preclinical models of pancreatitis
• · Apply modern molecular, biochemical and cell biological methods, including cell culture, flow cytometry, immunofluorescence microscopy, RNA and protein analysis and functional cellular assays
• · Contribute to the characterization of inflammatory, thrombotic and metabolic pathways using proteomic, lipidomic or transcriptomic approaches
• · Participate in the development and validation of targeted therapeutic strategies, including nanoparticle- and aptamer-based delivery approaches
• · Quantitatively analyze, interpret and document experimental and clinical research data
• · Collaborate closely with scientists, clinicians and technology platforms within the interdisciplinary Collaborative Research Centre
• · Present research findings at internal meetings and national and international scientific conferences and contribute to scientific publications

Our requirements

• · A successfully completed university degree, preferably a Master’s degree or equivalent, in biology, biochemistry, molecular medicine, biotechnology, pharmacy or a related life-science discipline
• · Strong interest in translational research, inflammation, pancreatitis, vascular biology or immunology
• · Practical experience in molecular and cell biology, for example mammalian cell culture, flow cytometry, microscopy, immunoblotting, quantitative PCR or functional cellular assays
• · Previous experience with primary cells, patient samples, animal models, proteomics, lipidomics, nanoparticles or drug-delivery systems is an advantage, but not mandatory
• · Motivation to learn new experimental technologies and quantitative analysis methods
• · A careful, structured and reliable approach to experimental work
• · Scientific curiosity, high motivation and the ability to work both independently and as part of a team
• · Strong communication skills and enthusiasm for working in an interdisciplinary and international research environment
• · Very good written and spoken English
• · German language skills are not required

Our offer

· An innovative PhD project within an interdisciplinary Collaborative Research Centre at LMU University Hospital

• · A translational research environment combining experimental pancreatitis research, vascular biology, immunology and clinical medicine
• · The opportunity to work with patient-derived biosamples, established disease models and modern molecular and imaging technologies
• · State-of-the-art laboratories and access to advanced flow cytometry, microscopy, proteomics, lipidomics and data-analysis platforms
• · Close collaboration with basic scientists, clinician scientists, bioinformaticians and experts in vascular and inflammatory biology
• · Integration into a highly collaborative national research network with opportunities for scientific exchange across several disciplines
• · Structured scientific supervision and support for professional and personal development
• · Opportunities to participate in scientific workshops, training programmes and national and international conferences
• · A supportive and inspiring working environment that encourages scientific independence and the development of new ideas
• · Employment according to the German public-sector collective agreement, including annual leave and additional benefits in accordance with the applicable regulations
• · The position is initially limited to three years. The precise wording regarding a possible extension should be adapted to the SFB funding conditions
• · The position is based at LMU University Hospital, Campus Großhadern, in Munich
• · Remuneration is based on the Collective Agreement for the Public Sector of the Länder (TV-L) including all allowances customary in the public sector.