Principal Scientist, Analytical Development, Oligo and Small Molecule

Location: This position may be performed remotely, but requires the flexibility and willingness to travel as needed.

Position Summary

The Principal Scientist, Analytical Development will play a critical role in advancing Praxis’ clinical and commercial pipeline by translating analytical strategies from development into manufacturing across our virtual network of CMOs and external partners.

This role is particularly focused on advancing oligonucleotide-based therapeutics, while also supporting small molecule programs across the portfolio. The individual will bring deep expertise in analytical method development, qualification, validation, troubleshooting, and GMP testing for oligonucleotide drug substances and drug products, with the ability to apply phase-appropriate analytical strategies across multiple modalities.

This is a highly cross-functional, hands-on leadership role requiring close partnership with Drug Substance, Drug Product, Quality, Regulatory, and Manufacturing teams to ensure robust, scalable, and compliant analytical control strategies. The successful candidate will help shape an agile, forward-looking analytical development function capable of supporting innovative CNS therapies from early development through commercialization.

Primary Responsibilities

Serve as Analytical Lead across CMC programs, with primary responsibility for oligonucleotide analytical development activities and support for small molecule programs

Lead analytical method development, qualification, validation, transfer, and GMP testing activities across internal teams and external partners

Drive technical troubleshooting, data interpretation, method lifecycle management, and review of analytical documentation including validation reports, stability reports, specifications, and CoAs

Design and implement phase-appropriate analytical control strategies, specifications, and stability programs for oligonucleotide and small molecule drug substances and drug products

Direct and manage CRO/CMO analytical partners to ensure high-quality execution, strong communication, and continuous operational improvement

Collaborate cross-functionally to strengthen CMC operations, improve processes, and establish scalable technical and business practices across the analytical function

Contribute strategic and technical expertise to support regulatory filings, commercialization readiness, and ongoing product lifecycle management

Qualifications and Key Success Factors

Advanced degree (PhD preferred; Master’s with significant industry experience considered) in Analytical Chemistry or related discipline with 5–7+ years of industry experience

Strong industry experience in analytical development for oligonucleotide drug substances and/or drug products required

Experience supporting small molecule drug substances and solid oral dosage forms strongly preferred

Deep knowledge of analytical techniques relevant to oligonucleotides, including impurity characterization, stability assessment, and GMP control strategies

Strong understanding of US and EU cGMP requirements and analytical best practices for drug substance and drug product development

Experience supporting CMC development across multiple stages of development, including regulatory submissions, validation, and commercialization activities

Experience managing external CRO/CMO analytical networks and building productive technical partnerships

Strong working knowledge of quality systems, reference standards, stability programs, and compendial testing requirements

Key Success Factors

Brings deep technical curiosity and strong scientific judgment, particularly in emerging oligonucleotide modalities

Operates with high ownership and accountability in fast-moving, ambiguous environments

Balances strategic thinking with hands-on execution and problem solving

Communicates clearly and collaborates effectively across functions and external partners

Continuously challenges assumptions and looks for smarter, more scalable ways of working

Thrives in agile environments that require adaptability, rigor, and urgency

Highly organized, detail-oriented, and motivated by delivering high-quality outcomes that advance therapies for patients

Annualized Base Salary

$170,000 — $190,000 USD

Compensation & Benefits

At Praxis, we believe that taking care of our people (and their people) is important, so we provide a world class benefits package to help you thrive. This includes 99% of the premium paid for medical, dental and vision plans. We also provide company-paid life insurance, AD&D, disability benefits, and voluntary plans to personalize your coverage. Thinking about the future? We match dollar-for-dollar up to 6% on eligible 401(k) contributions and sweeten the deal with long-term stock incentives and ESPP. We provide a discretionary quarterly bonus, an extremely flexible wellness benefit, generous PTO, paid holidays and company-wide shutdowns. Not to mention, you'll also be joining a phenomenal crew of colleagues who are smart, engaged and inspiring. We aim high, collaborate hard, and produce results. Let’s achieve the impossible together!

Company Overview

Praxis Precision Medicines is a clinical-stage biopharmaceutical company translating genetic insights into the development of therapies for central nervous system disorders characterized by neuronal imbalance. At Praxis we share a common vision of reshaping the human condition into a more freeing and fulfilled existence by developing high impact medicines for patients and families affected by and living with complex brain disorders. Our core Values of Trust , Ownership , Curiosity and Results are foundational to every aspect of our business and are exemplified by each and every one of our team members.

• Diversity, Equity & Inclusion
• Guided by our core values, at Praxis Precision Medicines, Inc. we continue to DARE FOR MORE ® to advance, promote, and champion diversity, equity, and inclusion by encouraging individuals to bring their authentic selves and perspectives to work each day. We are an equal opportunity employer and committed to providing opportunities to all qualified applicants without regard to race, religious creed, color, gender identity or expression, age, national origin, sexual orientation, disability, genetics, military service and veteran status, or any other characteristic protected by federal, state, or local laws.

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