Research Scientist II/Senior, Discovery Machine Learning

JOB SUMMARY

We are seeking skilled scientists to join our Discovery Machine Learning group at Iambic Therapeutics. In this role, you will be a key player in applying advanced ML techniques to support our drug discovery efforts and will be part of drug discovery teams pursuing important therapeutics across multiple indications. The work will include focus on our flagship machine learning models, including Enchant, our multimodal transformer model for predicting drug-target interactions and molecular properties. This role is based at our San Diego headquarters.

KEY RESPONSIBILITIES

Train, fine-tune, and evaluate machine learning models, assessing how they can best be leveraged in a drug-discovery setting and optimizing their performance

Partner with computational chemists, medicinal chemists and biologists to leverage ML insights for decision-making in high-throughput design-make-test-analyze cycles

Generate value, internally and for partners, from our machine learning models, and collaborate with other discovery teams to shape their use

Communicate results with internal drug discovery teams and machine learning scientists and externally with partners

Support the evolution of our machine learning models by gathering analytical feedback and delivering domain-driven guidance to the machine learning team

QUALIFICATIONS

Required:

PhD or equivalent degree in chemistry or another physical science with 3+ years of experience or commensurate degree and job experience. More junior candidates are welcome to apply, title will reflect experience.

Familiarity with using statistical analysis techniques to evaluate, troubleshoot, and adapt models in scientific contexts

Excellent written and verbal communication skills; must be able to articulate complex scientific concepts, technical challenges, and results clearly and concisely to diverse audiences.

Skills: Python programming, statistics, drug discovery

Strongly preferred:

PhD or equivalent degree in computational chemistry or machine learning in chemistry

3+ years of experience working in a drug discovery project

• ABOUT IAMBIC THERAPEUTICS
• Iambic Therapeutics (Nasdaq: IAM) is a technology and clinical-stage life sciences company headquartered in San Diego. By utilizing molecular superintelligence — integrating proprietary AI with automated, scalable chemistry and biology experimentation — our platform is designed to address the totality of drug discovery and development. At Iambic, we are building an engine that is designed to power the future of medicine. Learn more at iambic.ai .

• MISSION & VALUES
• Our mission is to make better technology for better medicines. Three values guide how we work:

Bold. We are courageous, take thoughtful risks, and approach challenges with tenacity.

Innovative. We are creative and find new solutions that deliver impact.

Collaborative. We respect one another and partner with integrity.

We value the range of perspectives our people bring, and we work to build an environment where every team member can contribute and grow.

• PAY AND BENEFITS
• The pay range for this role is listed above. Actual pay depends on factors including experience, skills, and location. Eligible employees in the U.S. receive company-paid medical coverage, flexible spending accounts, voluntary life insurance, 401(k) matching and flexible time off. We are in a brand-new state-of-the art facility in beautiful San Diego with a community gym, dining, and easy access to great places to live and play.

• EQUAL OPPORTUNITY
• Iambic is an equal opportunity employer. We consider all qualified applicants without regard to race, color, religion, sex, sexual orientation, gender identity or expression, national origin, ancestry, age, disability, medical condition, genetic information, marital status, veteran or military status, or any other characteristic protected by law.