Senior Engineer, MSAT

About the role

Sana Biotechnology is growing, and we are hiring new team members who believe in the potential of engineered cells as medicines, who are passionate about delivering the possible to patients, and who lead with the desire to work on novel ideas. As a Sr. MSAT Engineer, you will support manufacturing of Sana’s stem cell-derived pancreatic islet cell program for persons with type 1 diabetes (SC451). In collaboration with the Research team, you will scale, close, and automate the process in preparation for phase 1 clinical manufacturing. You will lead technology transfers to the manufacturing site. You will travel to the site to serve as person-in-plant during manufacturing runs.

What you’ll do

Apply engineering principles to scale-up, close, and automate PSC-based cell therapy manufacturing processes

Lead technology transfers and author technical documents including reports, standard operating procedures, master batch records, work instructions

Collaborate with Research to learn and document the process, and execute studies in the PD lab

Provide onsite support at the CDMO, develop a training plan for manufacturing operators, and oversee process execution

Review executed batch records, collaborate with QA to close process deviations, analyze manufacturing trends, and recommend improvements

Lead investigations to troubleshoot process execution challenges including RCA

Demonstrate ability to engage and effectively influence team members across multidisciplinary teams while prioritizing multiple projects and meeting deadlines

Drive curiosity, scientific rigor and excellent problem-solving skills across a fast-paced performance driven environment

What we’re looking for

BSc. and/or MS in Chemical, Biological, or Biomedical Engineering plus 7 yrs or equivalent combination of education and work experience

>4 years of experience with mammalian cell culture, including 1 year in cell therapy

Experience leading technology transfers to an external CDMO, preferably of cell therapy processes

Experience with adherent and suspension PSC culture and cell differentiation processes

Detail-oriented with good problem-solving, technical writing and verbal communication skills

Ability to effectively work in multidisciplinary teams, meet deadlines, and prioritize multiple projects

Aptitude for working in a self-driven, performance/results-oriented, fast-paced matrix environment

What will separate you from the crowd

Knowledge of PSC and pancreatic islet biology

Experience scaling-up a cell therapy manufacturing process to support phase 1 clinical trials

Well versed with cGMP requirements and working in a regulated environment, including experience as person-in-plan and/or GMP operator.

Working knowledge of statistical design of experiments (DoE) and RCA.

Operating knowledge of bioreactors, controlled-rate freezers, and other cell therapy equipment

Understanding of analytical methods such as flow cytometry

Experience developing scale down models

Excellent technical writing skills, including drafting IND sections

Familiar with R, Python, JMP and FlowJo software

What you should know

Travel to the manufacturing site ~25% of the time

Work in a laboratory environment ~25% of the time

Some weekend work required

Lift up to 25 lbs

Work within a cleanroom environment

The base pay range for this position at commencement of employment is expected to be between $160,000 and $190,000/year; however, base pay offered may vary depending on multiple individualized factors, including market location, job-related knowledge, skills, and experience

How we work together for patients

Lead from every seat – we seek to understand, act with honesty, and engage in the crucial conversations

Thrive as a team – we hire amazing people, are intensely curious, and cultivate inclusion and personal connectivity

Make it happen – we value vigorous debate, alignment around our decisions, and resilient execution

Get to know us

At Sana, we believe that a workforce with varied backgrounds strengthens us as a company and helps us to achieve our mission to meaningfully change the outcome of many human diseases. This belief is a pillar of our business and is critical to our success. Our goal is that Sana is the place for talented people to bring their authentic selves to work, to have a great career and to deeply, positively impact patients.

Core to our values, we believe there is nothing more important than the health and wellness of you and your family. For benefit eligible employees, we cover a generous portion of the cost for employee health coverage, making high-quality care more accessible and affordable. We offer ample time-off (various paid time off benefits, such as holidays, vacation, sick time, and parental leave), short- and long-term disability, employer paid basic life insurance, additional voluntary life insurance protection, financial wellness programs including financial planning resources, a 401(k) Plan with an immediately vested employer match, Tuition Reimbursement and Student Loan Repayment, Employee Stock Purchase Plan, commuter subsidy and a variety of wellness offerings to support each person individually. For more details on our benefits, visit Sana’s Benefits Portal .

We are committed to providing a workplace free of discrimination and harassment based on race, color, religion, age, gender, national origin, ancestry, physical or mental or sensory disability (including the use of a trained guide dog or service animal by a person with a disability), genetic information, actual or perceived HIV or Hepatitis C infection, medical condition (cancer or a record or history of cancer and genetic characteristics), marital status, sexual orientation, sexual preference, pregnancy (including childbirth and related medical conditions), disability, veteran status, political ideology, social class (including caste/caste identity), taking or requesting statutorily protected leave, status as a victim of domestic violence, sexual assault or stalking, or any other basis prohibited by applicable law.

To perform this job successfully, you must be able to perform each job responsibility satisfactorily. The job description listed above is representative of the knowledge, skills, and/or abilities required for this position. Reasonable accommodations may be made to enable individuals with disabilities to perform the functions described above.