Senior Principal Architect - Security Architecture & Solution Engineering - OT Security

GSK remains committed to achieving bold commercial ambitions for the future. By 2031, we aim to deliver £40 billion in annual sales, leveraging our existing strong performance momentum to significantly increase our positive impact on the health of billions of patients globally. Our Ahead Together strategy is centred on early intervention to prevent and alter the course of disease, thereby protecting people and supporting healthcare systems.

Our diverse portfolio consists of vaccines, specialty medicines, and general medicines.

Through continuous innovation and a dedicated focus on scientific and technical excellence, we strive to develop and launch new, groundbreaking treatments that address critical health challenges.

Position Summary

Own OT Security architecture across GSK's global manufacturing, laboratory and research estate, leading a team of seven. You own IEC 62443 zone and conduit design, Purdue model segmentation, safety system boundaries, OT vulnerability and detection architecture, and the convergence of IT and OT security controls in a GxP-validated environment.

About the team.

Security Architecture and Solution Engineering sets the target-state security architecture for GSK and builds the solutions that realise it. The function brings IT and OT architecture under single ownership for the first time, spanning Network and Zero Trust, Application Security, Platform Security, MDR and Detection Engineering, VM and Configuration Management, Data Security, and OT Security across a global manufacturing, laboratory and research estate. Architecture sets the standards and reference designs, Solution Engineering builds, tests and packages them, and a managed service vendor operates them. Architecture accountability never transfers: Cyber Architecture and Solutions designs and builds, the vendor runs. Twenty roles, with standards applying in more than 100 countries.

What makes this role different.

OT security in pharmaceutical manufacturing is not IT security applied to different hardware. A control that is routine in IT can halt a production line or invalidate a GxP validation, and change design has to account for that from the start. You will need genuine IEC 62443 and Purdue model depth — IT security leadership alone does not transfer, and the interview will test this directly. Your team spans the US, UK and India, and you will also hold Workday line management for three architects whose day-to-day work sits in other domains.

Key responsibilities:

This role will provide you the opportunity to lead key activities to progress your career. These responsibilities include some of the following:

Own OT security architecture across the global manufacturing, laboratory and research estate.

Own IEC 62443 zone and conduit design and Purdue model network segmentation.

Own safety system boundary design and the constraints that follow from GxP validation.

Own OT vulnerability management architecture where standard IT patching cannot be applied, including compensating control design.

Own OT asset discovery architecture across sites with incomplete inventories.

Own OT detection architecture for handoff to the Cyber Defence SOC, which operates it.

Drive convergence of IT and OT security controls without importing IT assumptions that break production.

Lead four OT architects across the US, UK and India, plus Workday line management for three architects whose functional work sits in other domains — an administrative rather than a technical responsibility.

Lead the OT architecture contribution to the Future Ready OT programme, GSK's multi-year effort to bring manufacturing and laboratory sites to a common OT security baseline.

Assure vendor handover for OT tooling and retain architecture accountability.

Lead your team in using approved AI tools to improve productivity and ways of working, role-modelling responsible use and follow GSK's Responsible AI, privacy and security requirements.

Evaluate and select OT security tooling against the architecture model, and own the cost and value of the OT security estate across the site portfolio.

Basic Qualifications:

15+ years in security architecture, including managing matrixed reports across geographies — domain focus: OT Security (OT, ICS and IoT across manufacturing, laboratory and research sites); domain authority aligned to IEC 62443 and the Purdue Model

OT network zone and conduit segmentation and OT monitoring integration using Claroty, Dragos or Nozomi Networks

OT vulnerability management where IT patching cannot be applied — compensating controls, automated asset discovery and risk posture reporting — and OT detection patterns and playbooks for the SOC and vendor

Leading an OT specialist team within GxP-validated manufacturing constraints, where a routine IT control can halt production

Applying AI and ML to OT security — anomaly detection in OT networks, AI-assisted asset discovery and secure adoption of AI in manufacturing

Preferred Qualifications:

Leading an OT transformation or Future Ready OT style programme at enterprise scale

OT asset discovery architecture across sites with incomplete or unreliable inventories

NIS2 scoping and reporting obligations for manufacturing sites in scope, and the evidence a competent authority expects.

OT risk posture reporting to executive leadership, including automated dashboards, and direct engagement with site engineering and operations teams

• •Partnering with Cyber Defence on OT threat exposure management and OT SOC handoffs
• •Qualifications: Bachelor's degree in a relevant discipline, or equivalent professional experience.
• •Typical tools and technologies: IEC 62443 zone and conduit design, Purdue model segmentation, OT monitoring platforms including Claroty, Dragos and Nozomi Networks, unidirectional gateways and data diodes, ICS, SCADA and PLC security patterns, OT asset discovery, safety instrumented system boundaries, OT vulnerability management and compensating controls, GxP-validated change control.

#AGTech

Skills

AI for Cybersecurity, Application Security, Cloud Security, Computer Programming, Data Security, Identity Access Management (IAM), Information Systems, Infrastructure Security, ML Security, Operating Systems Security, Scripting, Security Engineering, Security Technologies, Security Testing, Vulnerability Management

Why GSK?

Uniting science, technology and talent to get ahead of disease together.

GSK is a global biopharma company with a purpose to unite science, technology and talent to get ahead of disease together. We aim to positively impact the health of 2.5 billion people by the end of the decade, as a successful, growing company where people can thrive. We get ahead of disease by preventing and treating it with innovation in specialty medicines and vaccines. We focus on four therapeutic areas: respiratory, immunology and inflammation; oncology; HIV; and infectious diseases – to impact health at scale.

People and patients around the world count on the medicines and vaccines we make, so we’re committed to creating an environment where our people can thrive and focus on what matters most. Our culture of being ambitious for patients, accountable for impact and doing the right thing is the foundation for how, together, we deliver for patients, shareholders and our people.

Inclusion at GSK:

As an employer committed to Inclusion, we encourage you to reach out if you need any adjustments during the recruitment process.

Please contact our Recruitment Team at IN.recruitment-adjustments@gsk.com to discuss your needs.

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