Senior Research Associate, Genome Sciences & Engineering

About Stylus Medicine:

Stylus Medicine is developing transformative in vivo genetic medicines to unlock cures. Stylus combines engineered recombinases with non-viral delivery to specifically encode therapeutics. The company’s approach is versatile and modular, with potential therapeutic application across oncology, autoimmune, genetic diseases, and beyond.

About the Role:

Stylus Medicine is seeking a Senior Research Associate to join our Genome Sciences & Engineering team. In this role, the Senior Research Associate will drive the execution of cell-based assays and high-throughput screening workflows to advance the company’s LSR-based genome editing platforms. This role is ideal for a collaborative, organized, and creative scientist who thrives in a fast-paced environment and enjoys tackling complex problems to expand the frontiers of genome editing.

Key Responsibilities & Accountabilities:

Execute cell-based assays and high-throughput (HT) screening workflows that advance platform and program objectives, working both independently and as part of a cross-functional team

Develop and execute arrayed and pooled HT screening campaigns with rigor and reproducibility

Troubleshoot experiments, analyze data, and translate results into actionable scientific insights

Maintain detailed laboratory notebooks and clearly communicate data and findings to the broader scientific team

Partner cross-functionally to advance optimized candidates into translational and preclinical development

Qualifications & Skills:

BS with 3+ years or MS with 1+ years relevant experience in cell biology, molecular biology, or a related field

Experience conducting high-throughput cell-based screens; proficiency with primary T cells, hepatocytes, and/or cancer cell lines, working with LNPs preferred

Hands-on experience with gene editing technologies (e.g. CRISPR nucleases, recombinases, base editors, or transcriptional effectors)

Familiarity with laboratory automation platforms for cell-based screening workflows, flow cytometry

Experience with nucleic acid QC methods, including TapeStation, Qubit, NanoDrop, and qPCR

Track record of independently generating precise, reproducible data and performing rigorous quantitative analysis

Clear and approachable communication skills, with the ability to present technical information clearly and concisely to diverse audiences

Exceptional organizational skills and comfort managing complex datasets and overlapping projects

Strategic thinker who effectively plans and prioritizes to maximize scientific impact

Collaborative mindset with a team-first attitude

Creative problem-solver who thrives amid scientific uncertainty

Pay Range: $100,000 - $110,000