Senior Research Associate, Preclinical Pharmacology

Senior Research Associate, Preclinical Pharmacology

Run in vivo studies that move Nurix's degrader programs toward the clinic. You'll execute mouse efficacy, PK/PD, and mechanism-of-action studies in oncology and inflammation models and generate the Western blot and flow cytometry data that show how our molecules work.

Position Description

The Opportunity

Join the Research – Preclinical Pharmacology team as a full-time, onsite, hands-on member, reporting to a Scientist / Principal Scientist, Preclinical Pharmacology

Perform mouse handling and in-life procedures, including dosing by oral (PO), intraperitoneal (IP), subcutaneous (SC), and intravenous (IV) routes, tumor cell implantation, tumor and body-weight measurements, and in-life and terminal blood collection

Execute PK/PD, tolerability, and efficacy studies in oncology xenograft/syngeneic models and in murine models of inflammation, under the direction of study leads

Prepare and formulate test articles and vehicles for dosing; monitor animal health, document observations, and escalate adverse events promptly

Perform necropsy and collect, process, and bank tissues and blood for downstream biomarker and pharmacodynamic analyses

Prepare tissue and cell lysates and perform Western blotting (including quantitative and automated capillary formats) to measure target degradation and pathway modulation

Develop, run, and analyze multi-color flow cytometry panels for immune and tumor-cell phenotyping from blood, spleen, tumor, and other tissues

Maintain and expand cell lines using sterile cell culture technique; support cell-based assays and the generation of cells for in vivo implantation

Record experiments accurately and in a timely manner in the electronic lab notebook; analyze, graph, and summarize data and present results at team meetings

Collaborate with Biology, Chemistry, DMPK, and Translational teams to design studies and troubleshoot models and assays

Adhere to IACUC protocols, animal welfare regulations, and laboratory safety requirements, and maintain required training and certifications

Contribute to the optimization and qualification of new models and assays and to the training of junior team members

Maintain laboratory equipment and supplies and support vivarium coordination, including occasional weekend or off-shift study coverage; other essential duties as assigned; minimal travel (<5%)

What You’ll Bring

BS/MS in Biology, Pharmacology, Immunology, Cancer Biology, or a related field, with a BS or equivalent plus 8 or more years of relevant experience, or an MS plus 4 or more years of relevant experience

Industry (biotech or pharma) experience conducting in vivo pharmacology studies in mice

Proficiency in mouse handling and dosing by PO, IP, SC, and IV routes, as well as blood collection and tissue harvest

Hands-on experience with oncology models (e.g., xenograft, syngeneic) and with murine models of inflammation or immunology

Demonstrated proficiency in Western blotting and flow cytometry, including sample preparation, staining, and data analysis

Proficiency in sterile mammalian cell culture technique

Working knowledge of IACUC regulations and humane animal care practices

Strong organizational and documentation skills, with attention to detail and the ability to manage multiple studies simultaneously

Collaborative, adaptable, and comfortable in a fast-paced, team-oriented research environment

Ability to work in an animal facility and tolerate exposure to laboratory animals, and to work occasional weekends or off-shift hours as studies require

Bonus: experience with targeted protein degradation (molecular glues, PROTACs) or other small-molecule oncology or immunology programs

Bonus: experience with multi-spectral flow cytometry, automated Western (e.g., Jess/Wes), ELISA, or MSD cytokine/biomarker assays

Bonus: experience with orthotopic, disseminated, PDX, or humanized mouse models, or with in vivo imaging

Bonus: experience with inflammation models such as collagen-induced arthritis, colitis, or cytokine-challenge models

Bonus: familiarity with PK/PD relationships, compound formulation, and dose-response study design

Bonus: proficiency with GraphPad Prism and electronic lab notebook systems

Salary Range: $131,400 - $139,900

The posted range applies to roles based in the San Francisco Bay Area and reflects local market conditions. Where an offer lands within that range depends on the candidate’s relevant experience, technical expertise, and how their background aligns with the role’s requirements.

Location: Onsite – Brisbane, CA

Fit with Nurix Culture and Values

Strong team orientation; highly collaborative

Solutions and results-oriented focus

Hands-on approach; resourceful and open to diverse points of view

About Nurix Therapeutics

Nurix Therapeutics is a clinical stage biopharmaceutical company focused on the discovery, development, and commercialization of targeted protein degradation medicines, the next frontier in innovative drug design aimed at improving treatment options for patients with cancer and inflammatory diseases. Powered by a fully AI-integrated discovery engine capable of tackling any protein class, and coupled with unparalleled ligase expertise, Nurix’s dedicated team has built a formidable advantage in translating the science of targeted protein degradation into clinical advancements. Nurix aims to establish degrader-based treatments at the forefront of patient care, writing medicine’s next chapter with a new script to outmatch disease.