Sr Director, Commercial Finance

Definium Therapeutics is a late-stage clinical biopharmaceutical company and our mission is to forge a new era of psychiatry by applying scientific rigor to psychedelics, with the goal of developing accessible treatments that unlock healing at scale.

Our lead product candidate, lysergide tartrate (our proprietary orally disintegrating tablet form of lysergide (LSD) D-tartrate), represents a highly differentiated, potential best-in-class opportunity for patients suffering from generalized anxiety, major depressive disorder, and posttraumatic stress disorder. Our early stage pipeline includes DT402, the R-enantiomer of MDMA and is under development to target the core symptoms of autism spectrum disorder (ASD), specifically addressing social communication challenges.

Guided by the recognition that patients deserve more than better, Definium is relentlessly advancing a new generation of therapeutics intended to address the underlying causes of psychiatric and neurological disorders. By turning evidence into impact, Definium aims to change the trajectory of today’s mental health care crisis and enable a healthier future. Headquartered in New York, Definium Therapeutics trades on Nasdaq under the symbol DFTX.

Together we are moving psychiatry forward—beyond better, into a boundless future. Join us!

We are seeking an experienced and highly strategic Senior Director, Commercial Finance to lead the Commercial Finance function. This individual will serve as a key business partner to the Commercial Leadership team, providing financial leadership and decision support as the company evolves toward commercialization. The ideal candidate combines deep pharmaceutical or biotechnology commercial finance experience with the ability to operate effectively in a fast-paced, resource-conscious environment. This role will help establish the commercial finance infrastructure, processes, forecasting methodologies, performance metrics, and strategic decision-making capabilities needed to support a high-growth organization. Reporting to the VP, Finance & Strategy, the Senior Director will play a critical leadership role in long-range planning, revenue forecasting, launch readiness, resource allocation, and business performance management.

Responsibilities

Serve as the primary finance business partner to Commercial leadership, providing strategic financial guidance and decision support

Lead commercial financial planning processes, including annual budgets, quarterly forecasts, long-range planning, and scenario analysis.

Develop and maintain revenue forecasts, demand models, and commercial planning assumptions, partnering with Commercial Accounting on gross-to-net methodologies and financial implications of pricing, reimbursement, and market access strategies

Partner with Commercial leadership to assess commercial readiness, evaluate infrastructure and investment priorities, and support sales force sizing, territory planning, and resource optimization

Support product strategy, commercialization planning, and strategic initiatives through financial modeling, business case development, ROI analysis, competitive assessments, and market opportunity evaluations

Develop KPIs, dashboards, and reporting tools to track launch preparedness and commercial performance, providing actionable insights to support decision-making

Prepare analyses and presentations for Executive Leadership, Board meetings, and strategic planning discussions

Establish and scale the commercial finance function, including processes, systems, and best practices to support business growth

Partner with the broader FP&A organization to ensure alignment and consistency across corporate planning activities

Qualifications

Bachelor's degree in Finance, Accounting, Economics, Business, or a related field; MBA, CPA, or CFA preferred

Minimum 10 years of progressive finance experience, including significant FP&A and commercial finance leadership experience

Experience supporting commercial organizations within the pharmaceutical, biotechnology, or life sciences industries

Experience supporting commercial readiness activities, product launches, revenue forecasting, and market access planning

Strong understanding of pharmaceutical commercialization, pricing, reimbursement, and gross-to-net forecasting

Advanced financial modeling, forecasting, and analytical skills

Proven ability to influence cross-functional stakeholders and communicate effectively with senior leadership

Experience working in high-growth, dynamic environments with evolving business needs

Periodic travel may be required to support the commercial organization, strengthen business partnerships, and contribute to commercial launch readiness and execution. Travel frequency will vary based on business requirements, role responsibilities, and geographic location.

The starting base pay range for this position is $ $220,000.00-$270,000.00 Compensation will be determined based on several factors including, but not limited to, skill set, years of experience, and the employee’s geographic location.

Employees in this role may be entitled to additional compensation, including bonus and equity. Benefits information is listed on our Jobs Page. The Company provides competitive benefits to employees including:

100% paid health benefits including Medical, Dental and Vision for you and your dependents

401(k) program with company match and vesting after the turn of the first month after your start date

Flexible time off

Generous parental leave and some fun fringe perks!