Research Associate (m/f/d) - Translational Melanoma Research / 13784 / Department of Urology

• Research Associate (m/f/d) - Translational Melanoma Research
• (Entgeltgruppe: EG 13 TV-L)
• Einsatzbereich: Department of Urology - Research laboratory / Grünwald Lab
• Stellen ID: 13784
• Eintritt: Nächstmöglicher Zeitpunkt
• Umfang: Teilzeit / 25,025 h
• Vertragsart: Befristet
• Befristung: 30.06.2030

Ihre Aufgaben:

• •Opportunity to conduct high-level interdisciplinary research within the newly established DFG-funded Collaborative Research Centre CRC/SFB 1752 “DYNAMO – Immediate Tumor Dynamics in Melanoma Therapy”, investigating the earliest mechanisms of therapy resistance in melanoma during the first days and weeks after therapy initiation (“DYNAMO Window”); further information: [https://www.unidue.de/crc1752](https://www.unidue.de/crc1752)
• •Work in Project B02 “Microenvironmental drivers of constitutive HLA class II-positive melanoma cell states and their role in immediate therapy resistance”
• •Perform and integrate spatial and single-cell multi-omics analyses of functionally distinct immune niches within the melanoma tumor landscape
• •Develop and apply patient-derived co-culture, and fragment culture models to functionally dissect immune-modulatory mediators
• •Establish, optimize and/or perform cell type-resolved molecular analyses
• •Collaborate closely with computational and clinical consortium partners
• •Prepare manuscripts and present results at international conferences
• •Contribute to the translational development of advanced treatment strategies

Ihr Profil:

We seek an independent and motivated scientist with strong analytical and collaborative skills:

• •Completed Diploma or Master’s degree in cancer biology, molecular biology, biotechnology, biochemistry, bioinformatics or a related field
• •Strong background in tumor biology and/or tumor immunology
• •Experience with cell culture, functional assays and microscopy
• •Experience with or strong interest in spatial, single-cell, or multi-omics technologies
• •Ability to analyze high-dimensional data (R, Python or similar)
• •Interest in interdisciplinary translational research
• •Independent problem-solving skills and scientific creativity
• •Excellent teamwork and communication skills
• •Very good English (written and spoken)

Desirable

• •Experience in tumor microenvironment research and/or tissue-based analytics
• •Experience with complex model systems (organoids, spheroids or similar)
• •Knowledge of computational biology or image analysis

Freuen Sie sich auf:

• •Cutting-edge research & technology innovative project:
• •Participation in a newly established DFG-funded Collaborative Research
• •Centre featuring a strong interdisciplinary translational focus
• •Access to state-of-the-art technologies
• •Networking & collaboration scientific community:
• •Integration into an interdisciplinary, internationally visible cancer research network
• •Diverse teams: daily interaction with professional colleagues across experimental, computational, and clinical research
• •Exchange opportunities: excellent avenues for close scientific collaboration and external career development
• •Mentoring & career development:
• •Structured guidance: continuous, high-quality mentoring tailored to your academic progression
• •Enrollment into the Graduate School for Biomedical Science ‘BIOME’ ([https://www.uni-due.de/biome/)](https://www.uni-due.de/biome/))
• •Skill building: active participation in CRC events, lab rotations, hands-on workshops, and specialized training activities

A secure job in the public service of the state of NRW

Fair payment in accordance with the collective wage agreement (TV-L) incl. annual bonus payment and supplementary company pension scheme

30 days of vacation per calendar year (for a full-time position)

Interdisciplinary work with colleagues from other departments

Working with modern equipment and certified quality standards

Family-friendly corporate culture, e.g. company daycare center, vacation program for school-age children, advice and support from the Employee Service Office in all life situations

Wide range of training and continuing education opportunities, e.g. at the Training Academy of UK Essen

Health Management, e.g. company integration management, vaccinations, promotion of sports activities

Attractive fringe benefits, e.g. reduced-price canteen meals, community events, accommodation in student residences

Rahmenbedingungen: Die Eingruppierung richtet sich nach den persönlichen und tariflichen Voraussetzungen., Schwerbehinderte Bewerberinnen / Bewerber und Gleichgestellte i.S. des § 2 Abs. 3 SGB IX werden bei gleicher Eignung bevorzugt berücksichtigt., Im Falle einer schriftlichen Bewerbung reichen Sie Ihre Unterlagen nur als unbeglaubigte Kopien ein und verwenden Sie keine Mappen, da keine Rückgabe erfolgt. Eine Vernichtung entlang der datenschutzrechtlichen Bestimmungen wird zugesichert., Das UK Essen strebt eine Erhöhung des Frauenanteils in Bereichen an, in denen Frauen unterrepräsentiert sind. Sie werden zur Bewerbung aufgefordert und im Sinne des LGGs bei gleicher Qualifikation vorrangig berücksichtigt., Eine Bescheinigung gemäß §23a Infektionsschutzgesetz (IfSG) über den Impf- und Serostatus bzgl. Masern ist erforderlich.