Vice President of Information Technology

Olema Oncology is a clinical-stage biopharmaceutical company committed to transforming the standard of care and improving outcomes for patients living with breast cancer and beyond. With our transformation into a fully integrated oncology company well underway, it’s an exciting time to be part of Team Olema.

Our lead product candidate, palazestrant, is a novel, orally available complete estrogen receptor antagonist (CERAN) and selective estrogen receptor degrader (SERD) currently in two pivotal Phase 3 clinical trials. We expect top-line data from OPERA-01, our ongoing Phase 3 trial of palazestrant as a monotherapy in patients with second- or third-line ER+/HER2- metastatic breast cancer (MBC), in Q1 2027 which, if positive, could lead to our first potential approval and commercial launch in 2028. OPERA-02, our Phase 3 trial of palazestrant in combination with ribociblib in patients with frontline ER+/HER2- MBC, is enrolling patients. Together with its mechanism of action, pharmacokinetic properties, and the potential to demonstrate activity in both ESR1 wild-type and mutant tumors, palazestrant could transform the metastatic breast cancer treatment paradigm and provide access to a $15 billion global market opportunity.

Our follow-on product candidate, OP-3136, is a potent KAT6 inhibitor with the potential to generate further value and meaningfully impact the metastatic breast cancer treatment landscape – particularly in combination with palazestrant. We recently presented encouraging Phase 1 monotherapy data from this program across multiple solid tumor types, are advancing patient enrollment in the ongoing combination arms in MBC, and expect to initiate a Phase 1 study of OP-3136 in combination with Bayer’s darolutamide in metastatic castration-resistant prostate cancer by the end of this year.

Aspiring to transform the metastatic treatment paradigm is an ambitious endeavor that requires a resolute approach to developing better therapies and passionate colleagues dedicated to helping the patients we serve feel better, longer. Team Olema possesses a deep commitment to a shared purpose, the sustained pursuit of excellence, cultivating the courage required to advance our programs, the drive to succeed, and a collective capacity for adaptability through learning, growth, and evolution. We are a small group of nimble self-starters who bring consistency in our quest for the extraordinary every single day.

If you’re ready to be part of a tenacious, courageous, agile, and growing team, join us in making a profound impact, together – for our patients, for your career, and for what’s beyond.

About the Role >>> Vice President of Information Technology

The Vice President of Information Technology will serve as Olema’s senior technology leader and will own the strategy, security, and day-to-day operations and delivery of the global IT function. This leader will identify, build, and refine the new and existing systems, technology, tools, cybersecurity, and artificial intelligence capabilities the business requires as we advance our programs and toward our first potential product approval and commercial launch in the US.

The role will partner closely with leaders across the business, including Commercial, Medical Affairs, Regulatory Affairs, Quality, Clinical Development, Pharmacovigilance, Manufacturing and Supply Chain, and G&A. The ideal candidate will combine hands-on IT experience and leadership, deep Microsoft and O365 expertise, and demonstrable commercial launch experience with a strong enterprise-wide mindset and sound judgment in a fast-paced, highly regulated environment. This individual must also be an AI-forward leader and strong advocate for the rapid, responsible implementation of AI tools and frameworks to improve decision-making, productivity, service delivery, and organizational scalability.

This position is based in Olema’s San Francisco office and will require regular travel to Boston and Ireland, as needed.

Your w ork w ill p rimarily e ncompass :

Enterprise IT Strategy

Define and execute a multi-year enterprise IT strategy and applications roadmap aligned with business goals across research, development, commercial, and corporate functions.

Set efficient and scalable architecture, integration, cloud, SaaS, data, and technology lifecycle standards that support growth without unnecessary complexity.

Establish a strategic and effective IT operating model, including internal capabilities, outsourced services, governance, and decision rights .

Establish disciplined intake, prioritization, funding, and delivery processes that make value, cost, risk, capacity, and dependencies visible.

Advise the Executive Committee on technology investments, performance, cybersecurity, and risk .

O wn IT budgets, vendors, and major implementation partners.

IT Operations

A ccountable for the reliable operation of Olema's technology environment, including cloud services, networks, identity and access management, endpoints, collaboration platforms, telecommunications, conference-room technology, service desk, and end-user computing.

Ensure technology readiness for new offices, Ireland operations, commercial field teams, and workforce growth, including capacity planning, provisioning, connectivity, access, equipment, training, local support, and business continuity.

Own major IT incidents from detection through restoration, executive communication, root-cause analysis, and verified remediation. Ensure business-critical processes have tested recovery, manual workarounds, and accountable continuity plans.

Establish a senior client relationship model across every function, including regular roadmap reviews, service and project scorecards, demand planning, decision logs, and clear escalation paths. Ensure leaders understand priorities, constraints, ownership, and delivery commitments.

Partner with Finance to ensure systems and integrations support accurate , timely close and reporting, budgeting and forecasting, purchasing controls, vendor and expense management, SOX IT general controls, audit evidence, and scalable public-company operations.

Maintain disciplined technology asset and software license management across the full lifecycle, including procurement, deployment, inventory, maintenance, renewal, and secure disposition.

Develop effective IT reporting standards ( e.g., dashboards , scorecards, etc.) to communicate network performance , incident trends, resolution times, employee satisfaction, adoption, security, controls, project health, vendor performance, budget, technical debt, and launch readiness.

Set targets for major IT investments, measure benefits following implementation, and use results to guide priorities and funding. Own the outcomes after implementation. Confirm configuration quality, integration completeness, data quality, control effectiveness, adoption, performance, support readiness, and realized value before a system is considered fully delivered.

Lead IT -related vendor selection, contract negotiation, governance, performance management, and renewal decisions in partnership with Legal, Finance, Procurement, and business owners.

Build and lead a hig h- performing team of individual contributors , managers, contractors, and managed service p roviders appropriate for Olema’s stage and growth trajectory.

Regulatory Approval and Commercial Launch Readiness

Develop and o wn the integrated IT commercial readiness pla n based on anticipated regulatory approval and launch timelines. P artner with Commercia l and G&A leadership to define and execute the technology an d data roa dmap for launch.

Support C ommercial in identifying the platforms and services required for a successful launch , including customer relationship management, field systems, commercial data and analytics, master data, digital engagement, market access, and patient support capabilities.

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